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Pharmacokinetics, pharmacodynamics and toxicity of a combination of metoprolol succinate and telmisartan in Wistar albino rats: safety profiling.

Regulatory toxicology and pharmacology : RTP (2012-12-04)
Utpal Nandi, Sanmoy Karmakar, Anjan Kumar Das, Balaram Ghosh, Aswathi Padman, Nilendra Chatterjee, Tapan Kumar Pal
ABSTRACT

Metoprolol succinate (MET), a cardioselective β blocker and telmisartan (TEL), an angiotensin receptor blocker were administered orally, both individually and in combination to Wistar albino rats for evaluation of their pharmacokinetics, pharmacodynamics and repeated dose oral toxicity (28 days). Pharmacokinetic study was performed by analyzing drug concentration in plasma by a developed and validated LC-MS/MS method following oral administration of MET and TEL at 2.5 mg/kg and 2.0 mg/kg dose, respectively, both individually and in combination. Antihypertensive activity of MET and TEL in above dose and manner was evaluated on artificially induced hypertension on laboratory animals. In repeated dose oral toxicity study, MET (60, 120 and 240 mg/kg/day) and/or TEL (12, 24 and 48 mg/kg/day) were administered to animals for 28 days followed by a recovery period of 14 days. Pharmacokinetic data revealed the probable absence of any pharmacokinetic interaction when co-administered. Improved blood pressure lowering effect was observed by combination therapy. Moreover, toxic effects obtained at high dose level of each treatment groups were transient and reversible and no evidence of additive toxic effects were observed due to concomitant administration. So, this combination can primarily be stated as safe which will be confirmed after clinical interaction studies in humans.

MATERIALS
Product Number
Brand
Product Description

Telmisartan, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Telmisartan, ≥98% (HPLC), solid
Telmisartan for system suitability, European Pharmacopoeia (EP) Reference Standard
Telmisartan for peak identification, European Pharmacopoeia (EP) Reference Standard