Merck
  • Home
  • Search Results
  • Plasma AGE-peptides and C-peptide in early-stage diabetic nephropathy patients on thiamine and pyridoxine therapy.

Plasma AGE-peptides and C-peptide in early-stage diabetic nephropathy patients on thiamine and pyridoxine therapy.

Minerva medica (2013-02-09)
E Cetin, S Civelek, G Andican, F Candan Polizzi, V Yumuk, G Burçak
ABSTRACT

The aim of the study was to evaluate circulatory AGE-peptide levels in diabetic nephropathy and to observe the effects of thiamine (vitamin B1) and pyridoxine (vitamin B6) therapy. Type 2 diabetic patients (N.=57) were divided into two groups as "with nephropathy" (N.=27) and "without nephropathy" (N.=30). Diabetic nephropathy patients were treated with either B6 (N.=12) (250 mg/day) or B1+B6 (N.=15) (250 mg/day, each) for five months. At the beginning and the end of the experimentation period, glucose, HbA1c, triglyceride, cholesterol, insulin, C-peptide, thiamine pyrophosphate, pyridoxal phosphate and AGE- peptides were measured. AGE-peptides were higher in the diabetic group with nephropathy than without nephropathy (P=0.005). Within five months AGE-peptides increased in the diabetic group without nephropathy (P=0.042) but not in the group with nephropathy treated either with B1+B6 or B6. In B6 treated group a substantial decrease was observed in HbA1c (P=0.033). B1+B6 or B6 treatment both caused an increase in C-peptide (P=0.006, P=0.004). Among the parameters measured, plasma AGE-peptides was the only parameter found to be higher in type 2 diabetes mellitus patients "with nephropathy" than "without nephropathy". However, patients with nephropathy treated with B1+B6 or B6 did not display any further increase in AGE-peptides within five months. Both of the treatments caused an increase in C-peptide.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Pyridoxine hydrochloride, Vetec, reagent grade, 98%
Sigma-Aldrich
Pyridoxine hydrochloride
Pyridoxine hydrochloride, European Pharmacopoeia (EP) Reference Standard
Supelco
Pyridoxine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Pyridoxine Hydrochloride (B6), analytical standard
Sigma-Aldrich
Pyridoxine hydrochloride, ≥98% (HPLC)
Sigma-Aldrich
Pyridoxine hydrochloride, meets USP testing specifications
Sigma-Aldrich
Pyridoxine hydrochloride, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture
Sigma-Aldrich
Thiamine pyrophosphate, ≥95%
Sigma-Aldrich
Pyridoxine, ≥98%