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Receptor inactivation by dye-neuropeptide conjugates: 1. The synthesis of Cys-containing dye-neuropeptide conjugates.

Peptides (1996-01-01)
J J Feigenbaum, M D Choubal, K Payza, J R Kanofsky, D S Crumrine
ABSTRACT

In an attempt to attenuate specifically identified receptors through photolysis, a four-step synthesis is of a useful tethered derivative of Azure-B (Az) was developed After characterization, this derivative was covalently attached to CFMRFamide, CFMRF, and CLRFamide (i.e., three different neuropeptide analogues of the putative neurotransmitter FMRFamide. This resulted in the formation of three dye-neuropeptide conjugates: Az-CFMRFamide, Az-CFMRF, and Az-CLRFamide.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Azure B, certified by the Biological Stain Commission
Sigma-Aldrich
Azure B, prepared by direct synthesis