Formation cross sections and thick-target yields were studied in detail for alpha reactions and helium-3 reactions of natural cadmium in the energy range 10-40 MeV in order to determine the optimum condition for the production of medical use 11In. The helium-3 reactions were found to give higher 111In yield; namely, at the optimum helium-3 particle energy of 40 MeV and with the cadmium foil of 280 mg/cm2 thickness the amount of 11In produced was 270 muCi/muA . h. A cooling-time of 54 hours was required for the best radiochemical purity. The extraction of HBr-isopropyl ether followed by the anion exchange method was found to be the best chemical method for the carrier-free indium-111 separation.
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