Merck
  • Home
  • Search Results
  • Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases.

Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases.

Molecular cell (2014-04-15)
Gregory R Wagner, Matthew D Hirschey
ABSTRACT

Cellular proteins are decorated with a wide range of acetyl and other acyl modifications. Many studies have demonstrated regulation of site-specific acetylation by acetyltransferases and deacetylases. Acylation is emerging as a new type of lysine modification, but less is known about its overall regulatory role. Furthermore, the mechanisms of lysine acylation, its overlap with protein acetylation, and how it influences cellular function are major unanswered questions in the field. In this review, we discuss the known roles of acetyltransferases and deacetylases and the sirtuins as a conserved family of a nicotinamide adenine dinucleotide (NAD⁺)-dependent protein deacylases that are important for response to cellular stress and homeostasis. We also consider the evidence for an emerging idea of nonenzymatic protein acylation. Finally, we put forward the hypothesis that protein acylation is a form of protein "carbon stress" that the deacylases evolved to remove as a part of a global protein quality-control network.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
L-Lysine monohydrochloride, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
L-Lysine monohydrochloride, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Supelco
Activated charcoal, suitable for GC
Supelco
Activated charcoal, powder
Sigma-Aldrich
L-Lysine monohydrochloride, BioUltra, ≥99.5% (AT)
Supelco
Activated charcoal, puriss. p.a., powder
Supelco
Activated charcoal, for the determination of AOX, 50-150 μm particle size
Sigma-Aldrich
Carbon, glassy, spherical powder, 2-12 μm, 99.95% trace metals basis
Sigma-Aldrich
Activated charcoal, suitable for cell culture, suitable for plant cell culture
Supelco
L-Lysine monohydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
L-Lysine monohydrochloride, certified reference material, TraceCERT®
Carbon - Vitreous, rod, 5mm, diameter 3.0mm, glassy carbon
Carbon - Vitreous, foil, 25x25mm, thickness 0.5mm, glassy carbon
Carbon, foil, 100x100mm, thickness 1.0mm, flexible graphite, 99.8%
Sigma-Aldrich
L-Lysine monohydrochloride, Vetec, reagent grade, ≥98%
Carbon - Vitreous, foil, 8mm disks, thickness 1.0mm, glassy carbon
Carbon - Vitreous, foil, 8x8mm, thickness 0.5mm, glassy carbon
Carbon - Vitreous, rod, 200mm, diameter 10mm, glassy carbon
Carbon - Vitreous, foil, 100x100mm, thickness 6.0mm, glassy carbon
Carbon - Vitreous, rod, 100mm, diameter 3.0mm, glassy carbon
Carbon, foil, 100x100mm, thickness 0.2mm, flexible graphite, 99.8%
Carbon, foil, 100x100mm, thickness 0.35mm, flexible graphite, 99.8%
Carbon - Vitreous, foam, 150x150mm, thickness 3.2mm, bulk density 0.05g/cm3, porosity 96.5%
Carbon, foil, 100x100mm, thickness 1.0mm, rigid graphite, fine grain size, 99.95%
Carbon, foil, 100x100mm, thickness 0.5mm, flexible graphite, 99.8%
Carbon - Vitreous, foam, 150x150mm, 0.05g.cmué, porosity 96.5%, 24 pores/cm
Carbon, foil, 100x100mm, thickness 2.5mm, rigid graphite, fine grain size, 99.95%
Carbon - Vitreous, tube, 100mm, outside diameter 10mm, inside diameter 3mm, wall thickness 3.5mm, glassy carbon
Carbon - Vitreous, rod, 200mm, diameter 7.0mm, glassy carbon
Supelco
L-Lysine Acetate, Pharmaceutical Secondary Standard; Certified Reference Material