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Does the addition of pindolol accelerate or enhance the response to selective serotonin reuptake inhibitor antidepressants?

Pharmacotherapy (1999-02-25)
T Puzantian, K Kawase
ABSTRACT

Although in the last few years new antidepressants have become available in the United States, responses in many patients differ, from none, to partial, to delayed therapeutic response to the agents. If the antidepressant properties of these drugs could be enhanced or accelerated, it might be possible to improve patient functioning and quality of life. Pindolol, a serotonin 1A autoreceptor antagonist, accelerates and augments the therapeutic effects of antidepressants, especially selective serotonin reuptake inhibitors.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Pindolol, ≥98% (TLC), powder
Pindolol, European Pharmacopoeia (EP) Reference Standard