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Glyburide-induced cholestatic hepatitis and liver failure. Case-report and review of the literature.

The Netherlands journal of medicine (1992-06-01)
J P van Basten, B van Hoek, R Zeijen, R Stockbrügger
ABSTRACT

As sulphonylurea derivatives are used ubiquitously, the possibility that they may cause liver disease deserves attention. In contrast to the known pattern of reversible parenchymal liver disease due to sulphonylurea derivatives, we describe a fatal case of glyburide-induced cholestatic hepatitis with liver failure.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Glybenclamide, ≥99% (HPLC)
Sigma-Aldrich
Glyburide, meets USP testing specifications
Glybenclamide, European Pharmacopoeia (EP) Reference Standard
Glibenclamide for peak identification, European Pharmacopoeia (EP) Reference Standard
Supelco
Glyburide (Glibenclamide), Pharmaceutical Secondary Standard; Certified Reference Material