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Molybdenum metabolism in the alga Chlamydomonas stands at the crossroad of those in Arabidopsis and humans.

Metallomics : integrated biometal science (2011-05-31)
Angel Llamas, Manuel Tejada-Jiménez, Emilio Fernández, Aurora Galván
ABSTRACT

Molybdenum (Mo) is a very scarce element whose function is fundamental in living beings within the active site of Mo-oxidoreductases, playing key roles in the metabolism of N, S, purines, hormone biosynthesis, transformation of drugs and xenobiotics, etc. In eukaryotes, each step from Mo acquisition until its incorporation into a biologically active molybdenum cofactor (Moco) together with the assembly of this Moco in Mo-enzymes is almost understood. The deficiency in function of a particular molybdoenzyme can be critical for the survival of the organism dependent on the pathway involved. However, incapacity in forming a functional Moco has a pleiotropic effect in the different processes involving this cofactor. A detailed overview of Mo metabolism: (a) specific transporters for molybdate, (b) the universal biosynthesis pathway for Moco from GTP, (c) Moco-carrier and Moco-binding proteins for Moco transfer and (d) Mo-enzymes, is analyzed in light of recent findings and three systems are compared, the unicellular microalga Chlamydomonas, the plant Arabidopsis and humans.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Molybdenum, powder, <150 μm, 99.9% trace metals basis
Sigma-Aldrich
Molybdenum, powder, 1-5 μm, ≥99.9% trace metals basis
Sigma-Aldrich
Molybdenum, foil, thickness 0.1 mm, ≥99.9% trace metals basis
Sigma-Aldrich
Molybdenum, powder, <150 μm, 99.99% trace metals basis
Sigma-Aldrich
Molybdenum, foil, thickness 0.025 mm, ≥99.9% trace metals basis
Sigma-Aldrich
Molybdenum, nanopowder, <100 nm particle size (TEM), 99.8% trace metals basis
Sigma-Aldrich
Molybdenum, wire, diam. 1.0 mm, 99.95% trace metals basis
Sigma-Aldrich
Molybdenum, powder, 10 μm, ≥99.95% trace metals basis
Sigma-Aldrich
Molybdenum, foil, thickness 1.0 mm, ≥99.9% trace metals basis
Molybdenum, foil, 6mm disks, thickness 0.75mm, annealed, 99.9%
Molybdenum, rod, 100mm, diameter 15.0mm, centerless ground, 99.9%
Molybdenum, foil, 150x150mm, thickness 0.20mm, annealed, 99.9%
Molybdenum, foil, 6mm disks, thickness 0.5mm, annealed, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.005mm, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.006mm, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.007mm, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.008mm, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.009mm, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.0125mm, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.015mm, annealed, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.015mm, as rolled, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.01mm, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.01mm, annealed, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.020mm, annealed, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.025mm, annealed, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.03mm, annealed, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.05mm, annealed, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.075mm, annealed, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.125mm, annealed, 99.9%
Molybdenum, foil, 8mm disks, thickness 0.15mm, annealed, 99.9%