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Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)
A G Quiroga
ABSTRACT

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Platinum, wire, diam. 0.5 mm, 99.99% trace metals basis
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Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis
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Platinum, gauze, 100 mesh, 99.9% trace metals basis
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Platinum, wire, diam. 0.5 mm, 99.9% trace metals basis
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Platinum, wire, diam. 0.25 mm, 99.99% trace metals basis
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Platinum, powder, ≤10 μm, 99.9% trace metals basis
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Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis
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Platinum, nanopowder, 200 nm particle size (SEM), 99.9% (metals basis)
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Platinum, wire, diam. 0.10 mm, 99.99% trace metals basis
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Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis
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Platinum, foil, thickness 0.5 mm, 99.99% trace metals basis
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Platinum, foil, thickness 1.0 mm, 99.99% trace metals basis
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