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Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.

Dalton transactions (Cambridge, England : 2003) (2012-08-15)
Živadin D Bugarčić, Jovana Bogojeski, Biljana Petrović, Stephanie Hochreuther, Rudi van Eldik
ABSTRACT

A brief overview of mechanistic studies on the reactions of different Pt(II) complexes with nitrogen- and sulfur-donor biomolecules is presented. The first part describes the results obtained for substitution reactions of mono-functional Pt(II) complexes with different biomolecules, under various experimental conditions (temperature, pH and ionic strength). In addition, an overview of the results obtained for the substitution reactions of bi-functional Pt(II) complexes, analogous to cisplatin, with biomolecules is given. The last part of this report deals with different polynuclear Pt(II) complexes and their substitution behaviour with different biomolecules. The purpose of this perspective is to improve the understanding of the mechanism of action of Pt(II) complexes as potential anti-tumour drugs in the human body.

MATERIALS
Product Number
Brand
Product Description

Platinum, wire reel, 0.1m, diameter 0.5mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, wire reel, 5m, diameter 0.0125mm, hard, 99.9%
Platinum, foil, 0.2m coil, thickness 0.125mm, coil width 2.5mm, as rolled, 99.99%
Platinum, wire reel, 0.1m, diameter 0.01mm, wollaston, 99.9%
Platinum, foil, 0.5m coil, thickness 0.025mm, coil width 2mm, as rolled, 99.95%
Platinum, wire reel, 0.2m, diameter 0.001mm, wollaston, 99.9%
Platinum, foil, 0.5m coil, thickness 0.030mm, coil width .7mm, as rolled, 99.95%
Platinum, wire reel, 0.1m, diameter 1.0mm, as drawn, 99.99+%
Platinum, foil, 0.2m coil, thickness 0.030mm, coil width .7mm, as rolled, 99.95%
Platinum, wire reel, 0.2m, diameter 0.1mm, hard, 99.99%
Platinum, wire reel, 5m, diameter 0.015mm, annealed, 99.99%
Platinum, foil, 0.2m coil, thickness 0.025mm, coil width 2mm, as rolled, 99.95%
Platinum, wire reel, 0.1m, diameter 0.6mm, as drawn, 99.99+%
Platinum, foil, 10mm disks, thickness 0.005mm, as rolled, 99.95%
Platinum, foil, 0.05m coil, thickness 0.025mm, coil width .85mm, as rolled, 99.95%
Platinum, wire reel, 0.1m, diameter 0.001mm, wollaston, 99.9%
Platinum, wire reel, 0.2m, diameter 0.8mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, foil, 10mm disks, thickness 0.004mm, as rolled, 99.95%
Platinum, wire reel, 0.1m, diameter 0.005mm, wollaston, 99.9%
Platinum, foil, 15mm disks, thickness 0.004mm, as rolled, 99.95%
Platinum, foil, 1m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%
Platinum, foil, 0.05m coil, thickness 0.125mm, coil width 2.5mm, as rolled, 99.99%
Platinum, wire reel, 5m, diameter 0.01mm, hard, 99.9%
Platinum, foil, 0.2m coil, thickness 0.025mm, coil width 8mm, as rolled, 99.95%
Platinum, wire reel, 0.5m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, wire reel, 0.1m, diameter 0.0006mm, wollaston, 99.9%
Platinum, wire reel, 0.2m, diameter 1.0mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, wire reel, 2m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, foil, not light tested, 25x25mm, thickness 0.0025mm, as rolled, 99.95%
Platinum, wire reel, 20m, diameter 0.025mm, annealed, may be used as one component of a thermocouple, 99.99%