Merck

The role of zinc and copper in autism spectrum disorders.

Acta neurobiologiae experimentalis (2013-07-05)
Geir Bjorklund
ABSTRACT

Autism spectrum disorders (ASDs) are a group of developmental disabilities that can cause significant social, communication and behavioral challenges. Several studies have suggested a disturbance in the copper (Cu) and zinc (Zn) metabolism in ASDs. Zinc deficiency, excess Cu levels, and low Zn/Cu ratio are common in children diagnosed with an ASD. The literature also suggests that mercury accumulation may occur as a cause or consequence of metallothionein (MT) dysfunction in children diagnosed with an ASD, which may be one of the causes of Zn deficiency. MTs are proteins with important functions in metal metabolism and protection. Zinc and Cu bind to and participate in the control of the synthesis of MT proteins. Studies indicate that the GABAergic system may be involved in ASDs, and that Zn and Cu may play a role in this system.

MATERIALS
Product Number
Brand
Product Description

Copper - O.F.H.C., rod, 100mm, diameter 76mm, as drawn, 99.95+%
Copper - O.F.H.C., tube, 200mm, outside diameter 6.0mm, inside diameter 4mm, wall thickness 1.0mm, 99.95+%
Copper - O.F.H.C., foil, light tested, 100x100mm, thickness 0.075mm, half hard, 99.95+%
Copper - O.F.H.C., tube, 100mm, outside diameter 1.78mm, inside diameter 0.8mm, wall thickness 0.49mm, 99.95+%
Copper - O.F.H.C., foil, 6mm disks, thickness 0.7mm, half hard, 99.95+%
Copper - O.F.H.C., sheet, 100x100mm, thickness 3.0mm, 99.95+%
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Copper - O.F.H.C., foil, 8mm disks, thickness 0.006mm, hard, 99.95+%
Copper - O.F.H.C., rod, 200mm, diameter 50.0mm, as drawn, 99.95+%
Copper - O.F.H.C., tube, 200mm, outside diameter 1.23mm, inside diameter 0.51mm, wall thickness 0.36mm, 99.95+%
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