Merck

Ocular manifestations of monoclonal copper-binding immunoglobulin.

Survey of ophthalmology (2013-10-12)
Sejal Shah, Edgar M Espana, Curtis E Margo
PMID24112547
ABSTRACT

The dense accumulation of copper in Descemet membrane and lens capsule is the characteristic manifestation of a circulating monoclonal antibody with strong affinity for copper. The overproduction of this monoclonal immunoglobulin may be associated with either multiple myeloma or a benign monoclonal gammopathy. Despite prolonged exposure to elevated serum copper, no other tissues in the body are adversely affected by this redox metal. We describe the clinical and pathological findings in a 46-year-old woman with this disorder.

MATERIALS
Product Number
Brand
Product Description
223409
Sigma-Aldrich
Copper, shot, −3-+14 mesh, 99%
203122
Sigma-Aldrich
Copper, powder, 99.999% trace metals basis
311405
Sigma-Aldrich
Copper, ACS reagent, granular, 10-40 mesh, ≥99.90%
326453
Sigma-Aldrich
Copper, powder (spheroidal), 10-25 μm, 98%
349178
Sigma-Aldrich
Copper, foil, thickness 0.25 mm, 99.98% trace metals basis
520381
Sigma-Aldrich
Copper, spherical shot, −20-+30 mesh, ≥99.5% trace metals basis
326445
Sigma-Aldrich
Copper, bars (random sizes), ≥99.999% trace metals basis
BCR054R
Copper (O), BCR®, certified reference material, rod
IRMM522C
Copper, IRMM®, certified reference material, 0.5 mm wire
IRMM522A
Copper, IRMM®, certified reference material, 0.1 mm foil
767476
Sigma-Aldrich
Copper, sputtering target, diam. × thickness 2.00 in. × 0.25 in., 99.95% trace metals basis
266086
Sigma-Aldrich
Copper, powder, <425 μm, 99.5% trace metals basis
357456
Sigma-Aldrich
Copper, powder (dendritic), <45 μm, 99.7% trace metals basis
GF91850418
Copper, wire reel, 5m, diameter 0.75mm, as drawn, 99.98+%
GF92624496
Copper, wire reel, 50m, diameter 0.125mm, as drawn, 99.99+%
GF94573671
Copper, wire reel, 500m, diameter 0.04mm, hard, 99.9%
GF51040213
Copper, wire reel, 5m, diameter 0.02mm, hard, 99.99+%
GF06194077
Copper, wire reel, 25m, diameter 1.0mm, annealed, 99.9%
GF74431324
Copper, wire reel, 10m, diameter 0.05mm, as drawn, 99.99+%
GF74259771
Copper, wire reel, 50m, diameter 1.0mm, annealed, 99.9%
GF14187854
Copper, wire reel, 5m, diameter 0.02mm, annealed, 99.99%
GF45547331
Copper, wire reel, 50m, diameter 1.0mm, as drawn, 99.98+%
GF71276531
Copper - O.F.H.C., foil, light tested, 150x150mm, thickness 0.010mm, hard, 99.95+%
GF69182534
Copper - O.F.H.C., rod, 100mm, diameter 3.15mm, as drawn, 99.95+%
GF58890538
Copper - O.F.H.C., tube, 1000mm, outside diameter 4.0mm, inside diameter 3mm, wall thickness 0.5mm, 99.95+%
GF64538556
Copper - O.F.H.C., foil, not light tested, 50x50mm, thickness 0.006mm, hard, 99.95+%
GF15696243
Copper - O.F.H.C., rod, 100mm, diameter 25.4mm, as drawn, 99.95+%
GF53725563
Copper - O.F.H.C., rod, 1000mm, diameter 12.7mm, as drawn, 99.95+%
GF98815393
Copper - O.F.H.C., tube, 500mm, outside diameter 0.38mm, inside diameter 0.22mm, wall thickness 0.08mm, 99.95+%
GF61521320
Copper - O.F.H.C., sheet, 50x50mm, thickness 6.35mm, 99.95+%