Merck

Ocular manifestations of monoclonal copper-binding immunoglobulin.

Survey of ophthalmology (2013-10-12)
Sejal Shah, Edgar M Espana, Curtis E Margo
ABSTRACT

The dense accumulation of copper in Descemet membrane and lens capsule is the characteristic manifestation of a circulating monoclonal antibody with strong affinity for copper. The overproduction of this monoclonal immunoglobulin may be associated with either multiple myeloma or a benign monoclonal gammopathy. Despite prolonged exposure to elevated serum copper, no other tissues in the body are adversely affected by this redox metal. We describe the clinical and pathological findings in a 46-year-old woman with this disorder.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Copper, shot, −3-+14 mesh, 99%
Sigma-Aldrich
Copper, powder, 99.999% trace metals basis
Sigma-Aldrich
Copper, ACS reagent, granular, 10-40 mesh, ≥99.90%
Sigma-Aldrich
Copper, powder (spheroidal), 10-25 μm, 98%
Sigma-Aldrich
Copper, foil, thickness 0.25 mm, 99.98% trace metals basis
Sigma-Aldrich
Copper, spherical shot, −20-+30 mesh, ≥99.5% trace metals basis
Sigma-Aldrich
Copper, bars (random sizes), ≥99.999% trace metals basis
Copper (O), BCR®, certified reference material, rod
Copper, IRMM®, certified reference material, 0.5 mm wire
Copper, IRMM®, certified reference material, 0.1 mm foil
Sigma-Aldrich
Copper, sputtering target, diam. × thickness 2.00 in. × 0.25 in., 99.95% trace metals basis
Sigma-Aldrich
Copper, powder, <425 μm, 99.5% trace metals basis
Sigma-Aldrich
Copper, powder (dendritic), <45 μm, 99.7% trace metals basis
Copper, wire reel, 5m, diameter 0.75mm, as drawn, 99.98+%
Copper, wire reel, 50m, diameter 0.125mm, as drawn, 99.99+%
Copper, wire reel, 500m, diameter 0.04mm, hard, 99.9%
Copper, wire reel, 5m, diameter 0.02mm, hard, 99.99+%
Copper, wire reel, 25m, diameter 1.0mm, annealed, 99.9%
Copper, wire reel, 10m, diameter 0.05mm, as drawn, 99.99+%
Copper, wire reel, 50m, diameter 1.0mm, annealed, 99.9%
Copper, wire reel, 5m, diameter 0.02mm, annealed, 99.99%
Copper, wire reel, 50m, diameter 1.0mm, as drawn, 99.98+%
Copper - O.F.H.C., foil, light tested, 150x150mm, thickness 0.010mm, hard, 99.95+%
Copper - O.F.H.C., rod, 100mm, diameter 3.15mm, as drawn, 99.95+%
Copper - O.F.H.C., tube, 1000mm, outside diameter 4.0mm, inside diameter 3mm, wall thickness 0.5mm, 99.95+%
Copper - O.F.H.C., foil, not light tested, 50x50mm, thickness 0.006mm, hard, 99.95+%
Copper - O.F.H.C., rod, 100mm, diameter 25.4mm, as drawn, 99.95+%
Copper - O.F.H.C., rod, 1000mm, diameter 12.7mm, as drawn, 99.95+%
Copper - O.F.H.C., tube, 500mm, outside diameter 0.38mm, inside diameter 0.22mm, wall thickness 0.08mm, 99.95+%
Copper - O.F.H.C., sheet, 50x50mm, thickness 6.35mm, 99.95+%