Merck

Clinical safety of aspartame.

American family physician (1989-02-01)
D A Yost
ABSTRACT

Aspartame is a synthetic sweetener commonly used in soft drinks and many foods. Even with high doses, the metabolites of this sweetener do not accumulate in toxic amounts. To date, no definite symptom complex has been connected with aspartame, and it is considered safe for use in all populations, including diabetics, phenylketonuric heterozygotes and pregnant women.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Asp-Phe methyl ester, ≥98%
Supelco
Aspartame, analytical standard
Supelco
Aspartame, Pharmaceutical Secondary Standard; Certified Reference Material
Aspartame, European Pharmacopoeia (EP) Reference Standard
USP
Aspartame, United States Pharmacopeia (USP) Reference Standard