Merck

Aspartame: clinical update.

Connecticut medicine (1989-07-01)
D P Potenza, R S el-Mallakh
ABSTRACT

Since the introduction of aspartame into the American food supply in 1981, it has grown to become the most widely used and accepted artificial sweetener. However, recent published and unpublished reports of headaches, seizures, blindness, and cognitive and behavioral changes with long-term, high-dose aspartame may be cause for concern. Physician awareness of the present clinical and research status of aspartame is important.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Asp-Phe methyl ester, ≥98%
Supelco
Aspartame, analytical standard
USP
Aspartame, United States Pharmacopeia (USP) Reference Standard
Aspartame, European Pharmacopoeia (EP) Reference Standard
Supelco
Aspartame, Pharmaceutical Secondary Standard; Certified Reference Material