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Metabolism of dietary stearic acid relative to other fatty acids in human subjects.

The American journal of clinical nutrition (1994-12-01)
E A Emken
ABSTRACT

This paper reviews results obtained by stable-isotope-tracer methods for stearic acid (18:0) and palmitic acid (16:0) metabolism and the influence of dietary linoleic acid on the metabolism of these saturated fatty acids in humans subjects. The results, based on stable-isotope-tracer data, show that absorption of 18:0 is not significantly different from 16:0; percent desaturation of 18:0 to 9-cis 18:1 (9.2%) is 2.4 times higher than for 16:0 to 9-cis 16:1 (3.9%) and 9-desaturation is not greatly influenced by the amount of linoleic acid in typical US diets. Additionally, compared with 16:0, 18:0 incorporation is 30-40% lower for plasma triglyceride and cholesterol ester and approximately 40% higher for phosphatidylcholine; beta-oxidation of saturated fatty acids was slower than for unsaturated fatty acids and increasing the intake of dietary linoleic acid decreased beta-oxidation of saturated fatty acids. These results indicate that metabolic differences between 18:0 and 16:0 only partially explain the difference in the cholesterolemic effect reported for these saturated fatty acids.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Stearic acid, reagent grade, 95%
Sigma-Aldrich
Stearic acid, Grade I, ≥98.5% (capillary GC)
Sigma-Aldrich
Stearic acid, ≥95%, FCC, FG
Supelco
Stearic acid, analytical standard
Stearic acid, European Pharmacopoeia (EP) Reference Standard
Supelco
Stearic Acid, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Stearic acid, certified reference material, TraceCERT®
USP
Stearic acid, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Stearic acid, Vetec, reagent grade, 94%