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Understanding the relationship between DNA methylation and histone lysine methylation.

Biochimica et biophysica acta (2014-02-25)
Nathan R Rose, Robert J Klose
ABSTRACT

DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has become clear that the DNA and histone lysine methylation systems are highly interrelated and rely mechanistically on each other for normal chromatin function in vivo. Here we examine some of the functional links between these systems, with a particular focus on several recent discoveries suggesting how lysine methylation may help to target DNA methylation during development, and vice versa. In addition, the emerging role of non-methylated DNA found in CpG islands in defining histone lysine methylation profiles at gene regulatory elements will be discussed in the context of gene regulation.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
L-Lysine, Vetec, reagent grade, ≥98%
Supelco
L-Lysine, analytical standard
Lysine acetate, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
L-Lysine acetate salt, ≥98% (HPLC)
Sigma-Aldrich
L-Lysine, crystallized, ≥98.0% (NT)
Sigma-Aldrich
L-Lysine, ≥98% (TLC)
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L-Lysine monohydrochloride, BioUltra, ≥99.5% (AT)
Sigma-Aldrich
L-Lysine monohydrochloride, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
L-Lysine monohydrochloride, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Supelco
L-Lysine monohydrochloride, certified reference material, TraceCERT®
Supelco
L-Lysine monohydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
L-Lysine Acetate, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
L-Lysine monohydrochloride, Vetec, reagent grade, ≥98%
Lysine hydrochloride, European Pharmacopoeia (EP) Reference Standard