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Rickettsia parkeri rickettsiosis in different ecological regions of Argentina and its association with Amblyomma tigrinum as a potential vector.

The American journal of tropical medicine and hygiene (2014-10-29)
Yamila Romer, Santiago Nava, Francisco Govedic, Gabriel Cicuttin, Amy M Denison, Joseph Singleton, Aubree J Kelly, Cecilia Y Kato, Christopher D Paddock
ABSTRACT

Rickettsia parkeri, a newly recognized tick-borne pathogen of humans in the Americas, is a confirmed cause of spotted fever group rickettsiosis in Argentina. Until recently, almost all cases of R. parkeri rickettsiosis in Argentina have originated from the Paraná River Delta, where entomological surveys have identified populations of R. parkeri-infected Amblyomma triste ticks. In this report, we describe confirmed cases of R. parkeri rickettsiosis from Córdoba and La Rioja provinces, which are located several hundred kilometers inland, and in a more arid ecological region, where A. triste ticks do not occur. Additionally, we identified questing A. tigrinum ticks naturally infected with R. parkeri in Córdoba province. These data provide evidence that another human-biting tick species serves as a potential vector of R. parkeri in Argentina and possibly, other countries of South America.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Doxycycline hyclate
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Ethyl alcohol, Pure, 200 proof, meets USP testing specifications
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Potassium clavulanate, VETRANAL®, analytical standard
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Doxycycline hyclate, Pharmaceutical Secondary Standard; Certified Reference Material
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Ethanol solution, certified reference material, 2000 μg/mL in methanol
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Doxycycline monohydrate
USP
Doxycycline hyclate, United States Pharmacopeia (USP) Reference Standard
Doxycycline hyclate, European Pharmacopoeia (EP) Reference Standard
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Ethanol, absolute, denaturated with 0.5-1.5 Vol.% 2-butanone and approx. 0.001% Bitrex (GC), ≥98% (GC)