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In vitro antimicrobial activity of hydroxypyridinone hexadentate-based dendrimeric chelators alone and in combination with norfloxacin.

FEMS microbiology letters (2014-05-13)
Ying-Jun Zhou, Ming-Xia Zhang, Robert C Hider, Tao Zhou
ABSTRACT

The antimicrobial activity of one 3-hydroxypyridin-4-one (HPO) hexadentate (1) and three HPO hexadentate-based dendrimeric chelators (2-4) was evaluated. They were found to exhibit marked inhibitory effect on the growth of two Gram-positive bacteria and two Gram-negative bacteria. The combination treatment of dendrimeric chelator 2 with norfloxacin against Staphyloccocus aureus and Escherichia coli showed a dramatic synergistic bactericidal effect. As the dendrimeric chelator has a large molecular weight, its combination with norfloxacin may find application in the treatment of external infections.

MATERIALS
Product Number
Brand
Product Description

Norfloxacin for system suitability, European Pharmacopoeia (EP) Reference Standard
Supelco
Norfloxacin, analytical standard, ≥98% (TLC)
Supelco
Norfloxacin, VETRANAL®, analytical standard
Norfloxacin for peak identification, European Pharmacopoeia (EP) Reference Standard
Norfloxacin, European Pharmacopoeia (EP) Reference Standard