Merck
  • Home
  • Search Results
  • The effect of excipients on the stability and phase transition rate of xylazine hydrochloride and zopiclone.

The effect of excipients on the stability and phase transition rate of xylazine hydrochloride and zopiclone.

Journal of pharmaceutical and biomedical analysis (2015-01-16)
Kristīne Krūkle-Bērziņa, Andris Actiņš
ABSTRACT

The compatibility of thermodynamically unstable polymorph of two active pharmaceutical compounds (xylazine hydrochloride form X and zopiclone form C) with different excipients was investigated. The effects of the excipient and its amount in the sample on the thermal properties and possible chemical interactions were studied. The most commonly used excipients in the pharmaceutical industry - calcium carbonate, lactose hydrate, cellulose, magnesium stearate hydrate and calcium stearate hydrate were selected for this study. The dependence of the phase transition rate from an unstable to a more stable polymorph on the excipients and their amounts in the initial sample was analysed at 80°C, and the corresponding phase transition rate constants were calculated.

MATERIALS
Product Number
Brand
Product Description

Xylazine hydrochloride, European Pharmacopoeia (EP) Reference Standard
USP
Calcium Carbonate (AS), United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Xylazine hydrochloride, ≥99.0% (HPLC)
Supelco
Xylazine hydrochloride, VETRANAL®, analytical standard
Sigma-Aldrich
Calcium carbonate, tested according to Ph. Eur.
Millipore
Sucrose, ACS reagent, suitable for microbiology, ≥99.0%
Sigma-Aldrich
Sucrose, puriss., meets analytical specification of Ph. Eur., BP, NF
Sigma-Aldrich
Calcium carbonate, BioXtra, ≥99.0%
Supelco
Sucrose, analytical standard, for enzymatic assay kit SCA20
Sigma-Aldrich
Sucrose, meets USP testing specifications
Sigma-Aldrich
Sucrose, ≥99.5%
Sigma-Aldrich
Sucrose, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99.5% (GC)
Sigma-Aldrich
Sucrose, Grade I, suitable for plant cell culture
Sigma-Aldrich
Calcium carbonate, BioReagent, suitable for insect cell culture, ≥99.0%
Sigma-Aldrich
Sucrose, ACS reagent
Sigma-Aldrich
Sucrose, BioXtra, ≥99.5% (GC)
Sigma-Aldrich
Sucrose, for molecular biology, ≥99.5% (GC)
Sigma-Aldrich
Sucrose, Grade II, suitable for plant cell culture
Sigma-Aldrich
Sucrose, ≥99.5% (GC)
Sigma-Aldrich
Calcium carbonate, powder, ≤50 μm particle size, 98%
Sigma-Aldrich
Calcium carbonate, ACS reagent, chelometric standard, 99.95-100.05% dry basis
Sigma-Aldrich
Calcium carbonate, 99.999% trace metals basis
Sigma-Aldrich
Sucrose, BioUltra, for molecular biology, ≥99.5% (HPLC)
Sigma-Aldrich
Calcium carbonate, BioUltra, precipitated, ≥99.0% (KT)
Sigma-Aldrich
Lactose, tested according to Ph. Eur.
Supelco
Calcium carbonate, certified reference material for titrimetry, certified by BAM, ≥99.5%
Sigma-Aldrich
Calcium carbonate, ≥99.995% trace metals basis
USP
Sucrose, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Calcium carbonate, Vetec, reagent grade, 99%
Supelco
Sucrose, Pharmaceutical Secondary Standard; Certified Reference Material