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  • Tranexamic acid suppresses ultraviolet B eye irradiation-induced melanocyte activation by decreasing the levels of prohormone convertase 2 and alpha-melanocyte-stimulating hormone.

Tranexamic acid suppresses ultraviolet B eye irradiation-induced melanocyte activation by decreasing the levels of prohormone convertase 2 and alpha-melanocyte-stimulating hormone.

Photodermatology, photoimmunology & photomedicine (2014-07-25)
Keiichi Hiramoto, Yurika Yamate, Daijiro Sugiyama, Yumi Takahashi, Eiichi Mafune
ABSTRACT

Tranexamic acid (trans-4-aminomethylcyclohexanecarboxylic acid) is a medicinal amino acid used in skin whitening care. This study examined the effects of tranexamic acid on the melanocyte activation of the skin induced by an ultraviolet (UV) B eye irradiation. The eye or ear was locally exposed to UVB at a dose of 1.0 kJ/m(2) using a 20SE sunlamp after covering the remaining body surface with aluminum foil. UVB eye irradiation induced melanocyte activation of the skin, similar to that observed following UVB ear irradiation, which was suppressed by the administration of tranexamic acid treatment. The plasma α-melanocyte-stimulating hormone (α-MSH) content was increased by UVB irradiation of the eye; however, the increase in α-MSH was suppressed by tranexamic acid treatment. In addition, UVB eye irradiation induced the up-regulation of prohormone convertase (PC) 2 in the pituitary gland. Meanwhile, the increase in PC2 induced by UVB eye irradiation was suppressed by tranexamic acid treatment. These results clearly indicate that tranexamic acid decreases the expression of PC2, which cleavages from proopiomelanocortin to α-MSH in the pituitary gland, thereby suppressing melanocyte activation.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
3,4-Dihydroxy-L-phenylalanine, ≥98% (TLC)
Supelco
Levodopa, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
trans-4-(Aminomethyl)cyclohexanecarboxylic acid, 97%
USP
Tranexamic acid, United States Pharmacopeia (USP) Reference Standard
USP
Levodopa, United States Pharmacopeia (USP) Reference Standard
Tranexamic acid, European Pharmacopoeia (EP) Reference Standard
Levodopa, European Pharmacopoeia (EP) Reference Standard