• Home
  • Search Results
  • Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse.

Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse.

Neuroscience bulletin (2014-01-31)
Yan Hu, Sen Li, Hua Jiang, Ming-Tao Li, Jia-Wei Zhou
ABSTRACT

Postmitotic neurons in the neocortex migrate to appropriate positions and form layered structures of nascent cortex during brain development. The migration of these neurons requires precise control and coordination of a large number of molecules such as axon guidance cues. The Eph-ephrin signaling pathway plays important roles in the development of the nervous system in a wide variety of ways, including cell segregation, axon pathfinding, and neuron migration. However, the role of ephrin-B2/EphA4 signaling in cortical neuron migration remains elusive. Here we demonstrated that ephrin-B2 and its receptor EphA4 were expressed in complementary and overlapping patterns in the developing neocortex. Deletion of the EphA4 gene in the embryonic cerebral cortex resulted in faster migration of cortical neurons, whereas knockdown or overexpression of ephrin-B2 did not alter the normal process of migration. These results suggest that ephrin-B2 forward signaling through EphA4 is required for the precise control of cortical neuron migration.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Calcium phosphate, purum p.a., ≥96.0% (calc. as Ca3(PO4)2, KT)
Sigma-Aldrich
β-tri-Calcium phosphate, puriss. p.a., ≥98% β-phase basis (sintered Powder)
Sigma-Aldrich
β-tri-Calcium phosphate, puriss. p.a., ≥98% β-phase basis (unsintered powder)
Sigma-Aldrich
β-tri-Calcium phosphate, puriss. p.a., ≥95% β-phase basis (sintered powder)
Sigma-Aldrich
α-Tri-Calcium phosphate, Reagent for transient & stable DNA transfections
Sigma-Aldrich
Anti-Ephrin-B2 antibody produced in goat, affinity isolated antibody
Sigma-Aldrich
Anti-EFNB2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution
Sigma-Aldrich
MISSION® esiRNA, targeting human EFNB2
Sigma-Aldrich
MISSION® esiRNA, targeting mouse Efnb2

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.