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  • Voxel-based correlation between whole-brain CT perfusion with 320-row area detector ct and iodine 123 iodoamphetamine brain perfusion spect in patients with cerebrovascular disease.

Voxel-based correlation between whole-brain CT perfusion with 320-row area detector ct and iodine 123 iodoamphetamine brain perfusion spect in patients with cerebrovascular disease.

Journal of computer assisted tomography (2014-07-10)
Kazuhiro Murayama, Hiroshi Toyama, Motoharu Hayakawa, Shuei Imizu, Tsutomu Soma, Akira Taniguchi, Kazuhiro Katada
ABSTRACT

We compared cerebral blood flow (CBF) measured using computed tomographic (CT) perfusion (CTP) and N-isopropyl-p-[(123) I]-iodoamphetamine cerebral perfusion single-photon emission computed tomography (SPECT). We used a 320-row area detector CT and N-isopropyl-p-[(123) I]-iodoamphetamine cerebral perfusion SPECT under similar conditions in patients with chronic cerebrovascular disease. Images were automatically aligned 3-dimensionally for voxel-by-voxel comparisons. Linear positive correlations were observed between CTP-CBF including high-blood-flow areas and SPECT-CBF over the whole brain (r = 0.001-0.6, P < 0.01), superior cerebral level (r = 0.45-0.93, P < 0.01), basal ganglia level (r = 0.44-0.77, P < 0.01), and skull base (r = 0.02-0.66, P < 0.01). Correlations between CTP-CBF excluding high-blood-flow areas were significantly higher (P < 0.0001). Computed tomographic perfusion overestimated CBF compared with SPECT and showed poor correlation at the skull base. Computed tomographic perfusion CTP excluding high-blood-flow areas improved the correlation over the whole brain in patients with chronic cerebrovascular disease.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Iodine, puriss., meets analytical specification of Ph. Eur., BP, USP, 99.8-100.5%
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Iodine, ReagentPlus®, ≥99.8% (titration)
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Iodine, anhydrous, beads, −10 mesh, 99.999% trace metals basis
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