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Synthesis of ZnO nanorods and their application in the construction of a nanostructure-based electrochemical sensor for determination of levodopa in the presence of carbidopa.

The Analyst (2014-07-12)
Elahe Molaakbari, Ali Mostafavi, Hadi Beitollahi, Reza Alizadeh
ABSTRACT

A novel carbon paste electrode modified with ZnO nanorods and 5-(4'-amino-3'-hydroxy-biphenyl-4-yl)-acrylic acid (3,4'-AAZCPE) was fabricated. The electrochemical study of the modified electrode, as well as its efficiency for the electrocatalytic oxidation of levodopa, is described. The electrode was employed to study the electrocatalytic oxidation of levodopa, using cyclic voltammetry (CV), chronoamperometry (CHA), and square-wave voltammetry (SWV) as diagnostic techniques. It has been found that the oxidation of levodopa at the surface of the modified electrode occurs at a potential of about 370 mV less positive than that of an unmodified carbon paste electrode. The SWV results exhibit a linear dynamic range from 1.0 × 10(-7) M to 7.0 × 10(-5) M and a detection limit of 3.5 × 10(-8) M for levodopa. In addition, this modified electrode was used for the simultaneous determination of levodopa and carbidopa. Finally, the modified electrode was used for the determination of levodopa and carbidopa in some real samples.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
3,4-Dihydroxy-L-phenylalanine, ≥98% (TLC)
Supelco
Levodopa, Pharmaceutical Secondary Standard; Certified Reference Material
USP
Levodopa, United States Pharmacopeia (USP) Reference Standard
USP
Carbidopa, United States Pharmacopeia (USP) Reference Standard
Levodopa, European Pharmacopoeia (EP) Reference Standard
Carbidopa, European Pharmacopoeia (EP) Reference Standard