L040080

Sigma-Aldrich

Cap A

configured for PerkinElmer, configured for Polygen

NACRES:
NA.21

Quality Level

type

for DNA synthesis

product line

Proligo Reagents

assay

88.7-108.4 g/L (Acetic Anhydride content, titration)

storage condition

dry at room temperature

color

clear

compatibility

configured for PerkinElmer
configured for Polygen

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Packaging

4×2, 4 L in glass bottle
6×200 mL in glass bottle

Preparation Note

Acetic Anhydride / Tetrahydrofurane 9.1/90.9 (v/v)

Other Notes

Cap A solution, containing acetic anhydride and tetrahydrofuran (THF), is used after the phosphoramidite reaction/coupling step. This solution aborts chains bearing unreacted 5′hydroxyl groups due to failure of reaction with activated phosphoramidite (typically, 1 to 2% of growing oligonucleotide chains in each synthesis cycle). These unreacted 5′hydroxyl groups are capped with an acetyl group and thus rendered unreactive for subsequent synthesis steps.

Signal Word

Danger

Supp Hazards

EUH019 - EUH071

RIDADR

UN 2056 3 / PGII

WGK Germany

WGK 1

Flash Point(F)

-6.2 °F - closed cup

Flash Point(C)

-21.2 °C - closed cup

Certificate of Analysis
Certificate of Origin

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