29992

Sigma-Aldrich

DL-α-Tocopherol acetate

tested according to Ph. Eur.

Synonym(s):
α-Tocopherylis acetas, Vitamin E acetate, all-rac-α-Tocopheryl acetate
Empirical Formula (Hill Notation):
C31H52O3
CAS Number:
Molecular Weight:
472.74
Beilstein/REAXYS Number:
97512
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.26

Quality Level

biological source

synthetic

Agency/Method

USP/NF
tested according to Ph. Eur.

assay

96.5-102.0%

form

liquid

application(s)

cell analysis: suitable

density

0.96 g/mL at 20 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

storage temp.

2-8°C

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

InChI key

ZAKOWWREFLAJOT-CEFNRUSXSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

α-Tocopherol is a form of vitamin E. Vitamin E can be obtained through dietary sources. RRR‐α‐tocopherol is a natural form of α-Tocopherol.

Application

DL-alpha-Tocopherol acetate was used as a vitamin E supplement for studying whether the addition of an antioxidant or vitamin E in the diet of rats with dextran sulfate sodium (DSS)-induced colitis can reduce detrimental impact of inflammatory bowel disease.

Biochem/physiol Actions

Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by Homosapiens. DL-α-Tocopherol acetate can inhibit oxidation of linoleate.
α-Tocopherol is also known as a radical-chain breaker due to its anti-oxidant property.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

437.9 °F - closed cup

Flash Point(C)

225.5 °C - closed cup

Certificate of Analysis
Certificate of Origin
S Grossman et al.
The International journal of biochemistry, 16(3), 281-289 (1984-01-01)
The formation of alpha-tocopherol--lipoxygenase complex was elucidated using immobilized affinity purified soybean lipoxygenase and [D-3H]alpha-tocopherol. The alpha-tocopherol--lipoxygenase complex did not dissociate on addition of linoleic acid. Iodoacetate modified immobilized lipoxygenase did not form the complex with alpha-tocopherol. Lipoxygenase attached to...
Julie Carrier et al.
The Journal of nutrition, 132(10), 3146-3150 (2002-10-09)
Inflammatory bowel disease is often associated with iron deficiency anemia and oral iron supplementation may be required. However, iron may increase oxidative stress through the Fenton reaction and thus exacerbate the disease. This study was designed to determine in rats...
alpha-Tocopherol stereoisomers
Jensen S K and Lauridsen C
Vitamins and Hormones, 76(3), 281-308 (2007)
Vitamin E supplementation and cardiovascular events in high-risk patients.
Yusuf S, et al.
The New England Journal of Medicine, 342(3), 154-160 (2000)
Absorption, transport, and tissue delivery of vitamin E
Rigotti A
Molecular Aspects of Medicine, 28(5-6), 423-436 (2007)
Articles
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
Read More

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.