32071

Supelco

Nafcillin sodium salt

VETRANAL®, analytical standard

Synonym(s):
(2S,5R,6R)-6-{[(2-Ethoxy-1-naphthalenyl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt, 6-(2-Ethoxy-1-naphthamido)penicillin sodium salt
Empirical Formula (Hill Notation):
C21H21N2NaO5S
CAS Number:
Molecular Weight:
436.46
EC Number:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

VETRANAL®

form

neat

shelf life

limited shelf life, expiry date on the label

application(s)

HPLC: suitable
gas chromatography (GC): suitable

Featured Industry

Clinical
Forensics and Toxicology
Pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C21H22N2O5S.Na/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23;/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27);/q;+1/p-1/t15-,16+,19-;/m1./s1

InChI key

AYAPZOUDXCDGIF-FRFVDRIFSA-M

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General description

Nafcillin is a penicillin antibiotic used mostly in treating mastitis of cows.
Chemical structure: ß-lactam

Application

Nafcillin sodium salt (NF-PC) has been used as working standard in HPLC analysis to determine β-lactam antibiotics from milk samples and in LC–MS–MS analysis to determine NF-PC in bovine tissues.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
David Buechner et al.
Journal of neurosurgery, 117(1), 103-106 (2012-05-15)
Arterial large vessel vasculopathy is an unusual complication of bacterial meningitis in adults that may result in cerebral ischemia and severe neurological sequelae. Previous therapy has included antimicrobials with no specific vascular interventions. The authors report their experience with a...
John F Kokai-Kun et al.
The Journal of antimicrobial chemotherapy, 64(1), 94-100 (2009-04-29)
Staphylococcus aureus infections associated with indwelling devices can be very difficult to treat due to the recalcitrant nature of bacterial biofilms to conventional antibiotics. Lysostaphin has been shown to clear S. aureus biofilms in vitro, and in this study we...
Mine-Ok Chang et al.
Internal medicine (Tokyo, Japan), 51(3), 287-289 (2012-02-02)
Nafcillin is an antibiotic used for infections due to penicillin-resistant Staphylococcus aureus. In general, the adverse reactions to nafcillin have not been frequent and serious. We report here a new type of adverse reaction to nafcillin in a patient with...
Application of ion-exchange cartridge clean-up in food analysis IV. Confirmatory assay of benzylpenicillin, phenoxymethylpenicillin, oxacillin, cloxacillin, nafcillin and dicloxacillin, in bovine tissues by liquid chromatography-electrospray ionization tandem mass spectrometry.
Ito Y
Journal of Chromatography A, 911(2), 217-223 (2001)
Thromboembolic events of mitral valve endocarditis.
Marc L Baker et al.
Cardiology journal, 17(2), 192-193 (2010-06-15)

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