75281

Supelco

N-Nitrosoanatabine

analytical standard

Empirical Formula (Hill Notation):
C10H11N3O
CAS Number:
Molecular Weight:
189.21
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

analytical standard

assay

≥97.0% (HPLC)

form

neat

shelf life

limited shelf life, expiry date on the label

application(s)

HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable

Featured Industry

Cleaning Products
Cosmetics
Food and Beverages
Personal Care

format

neat

storage temp.

2-8°C

SMILES string

O=NN1CC=CCC1c2cccnc2

InChI

1S/C10H11N3O/c14-12-13-7-2-1-5-10(13)9-4-3-6-11-8-9/h1-4,6,8,10H,5,7H2

InChI key

ZJOFAFWTOKDIFH-UHFFFAOYSA-N

General description

Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706031. N-Nitrosoanatabine (NAT), classified in the third group of carcinogens, belongs to the class of tobacco-specific nitrosamines (TSNAs). TSNAs are carcinogenic compounds, formed through the burning, curing and fermentation of tobacco leaves. Their levels in tobacco can vary and significantly correlate to the amount of nitrate in tobacco. NAT is produced together with N′-nitrosonornicotine [NNN] and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone [NNK]) in tobacco. It can be detected in E-cigarette cartridges, mainstream tobacco smoke, snuff, etc.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
N-Nitrosoanatabine has been used as an analytical reference standard for the quantification of the analyte in urine samples using SupelMIP solid phase extraction (SPE) followed by liquid chromatography coupled to mass spectrometry (LC-MS). It may also be used as an analytical reference standard for the quantification of the analyte in human urine samples, replacement liquids of electronic cigarettes, snuff samples using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 2810 6.1 / PGIII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Analytical method for measurement of tobacco-specific nitrosamines in E-cigarette liquid and aerosol
Lee S-Y, et al.
Applied Sciences, 8(12), 2699-2699 (2018)
Adrian A Franke et al.
Drug testing and analysis, 8(10), 1095-1099 (2015-12-02)
Approximately 600 million people worldwide practise the carcinogenic habit of betel nut/quid chewing. Carcinogenic N-nitroso compounds have been identified in saliva or urine of betel chewers and the betel alkaloid arecoline in hair from habitual betel quid chewers. However, the...
N-Nitroso compounds in cigarette tobacco and their occurrence in mainstream tobacco smoke
Tricker RA, et al.
Carcinogenesis, 12(2), 257-261 (1991)
Determination of tobacco-specific nitrosamines in replacement liquids of electronic cigarettes by liquid chromatography?tandem mass spectrometry
Kim J-H and Shin S-H
Journal of Chromatography A, 1291, 48-55 (2013)
Tobacco Control, An Issue of Nursing Clinics-E-Book, 47(1) (2012)

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