84071

SAFC

Ruthenium Red

for microscopy, ≥85% (calc. on dry substance, AT)

Synonym(s):
Ammoniated ruthenium oxychloride
Linear Formula:
[(NH3)5RuORu(NH3)4ORu(NH3)5]Cl6
CAS Number:
Molecular Weight:
786.35
Colour Index Number:
77800
MDL number:
PubChem Substance ID:

grade

for microscopy

assay

≥85% (calc. on dry substance, AT)

impurities

~5% water

SMILES string

N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru++]O[Ru++]O[Ru++]

InChI

1S/6ClH.14H3N.2O.3Ru/h6*1H;14*1H3;;;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6

InChI key

ZXYSDUPLHOJIOR-UHFFFAOYSA-H

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Application

Inhibits mitochondrial Ca2+ uniporter; capsaicin antagonist; blocks VR1 vanilloid receptor-coupled ion channels.

Other Notes

Interaction with calcium-binding proteins

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
J H Charuk et al.
Analytical biochemistry, 188(1), 123-131 (1990-07-01)
The interaction of ruthenium red, [(NH3)5Ru-O-Ru(NH3)4-O-Ru(NH3)5]Cl6.4H2O, with various Ca2(+)-binding proteins was studied. Ruthenium red inhibited Ca2+ binding to the sarcoplasmic reticulum protein, calsequestrin, immobilized on Sepharose 4B. Furthermore, ruthenium red bound to calsequestrin with high affinity (Kd = 0.7 microM;...
Cyrielle Corbin et al.
Ultrasonics sonochemistry, 26, 176-185 (2015-03-11)
Flaxseed accumulates in its seedcoat a macromolecular complex composed of lignan (secoisolariciresinol diglucoside, SDG), flavonol (herbacetin diglucoside, HDG) and hydroxycinnamic acids (p-couramic, caffeic and ferulic acid glucosides). Their antioxidant and/or cancer chemopreventive properties support their interest in human health and...
Gregory M Pask et al.
PloS one, 6(12), e28774-e28774 (2011-12-17)
Insect odorant receptors (ORs) function as odorant-gated ion channels consisting of a conventional, odorant-binding OR and the Orco coreceptor. While Orco can function as a homomeric ion channel, the role(s) of the conventional OR in heteromeric OR complexes has largely...
Aleksandr Gavrin et al.
The Plant cell, 26(9), 3809-3822 (2014-09-14)
In legume-rhizobia symbioses, the bacteria in infected cells are enclosed in a plant membrane, forming organelle-like compartments called symbiosomes. Symbiosomes remain as individual units and avoid fusion with lytic vacuoles of host cells. We observed changes in the vacuole volume...
Marco Schlepütz et al.
PloS one, 7(10), e47344-e47344 (2012-10-12)
The peripheral airway innervation of the lower respiratory tract of mammals is not completely functionally characterized. Recently, we have shown in rats that precision-cut lung slices (PCLS) respond to electric field stimulation (EFS) and provide a useful model to study...

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