G7126

Sigma-Aldrich

Glycine

ReagentPlus®, ≥99% (HPLC)

Synonym(s):
Aminoacetic acid, Aminoethanoic acid, Glycocoll
Linear Formula:
NH2CH2COOH
CAS Number:
Molecular Weight:
75.07
Beilstein/REAXYS Number:
635782
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

Quality Level

product line

ReagentPlus®

assay

≥99% (HPLC)

form

powder

application(s)

western blot: suitable

impurities

≤0.01% Ammonia

loss

≤0.2% loss on drying

color

white to off-white

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

solubility

H2O: 200 mg/mL, clear, colorless to faintly yellow

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Gene Information

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General description

Glycine is a non-chiral amino acid. Glycine is a molecule with pI of 6.7, which is similar to the pH of stacking region in polyacrylamide gels. It has advantage of low mobility, hydrophobicity and it does not associate with proteins.

Application

  • Glycine has been added in the transfer buffer during western blotting procedure.
  • It has been used in the solution prepared for dissolving formazan crystals in the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) cytotoxicity assay.
  • It has been used for terminating the rat basophilic leukemia (RBL) assay.

Packaging

5, 25 kg in poly drum
10 mg in glass bottle
1 kg in poly bottle
100, 500 g in poly bottle

Biochem/physiol Actions

Glycine is an inhibitory neurotransmitter in the central nervous system and works as an allosteric regulator of NMDA (N-methyl-D-aspartate) receptors. It is involved in processing of motor and sensory data, thereby regulating movement, vision and audition.
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Certificate of Analysis

Certificate of Origin

A functional study on the migration of human monocytes to human leukemic cell lines and the role of monocyte chemoattractant protein-1.
Legdeur MC et al.
Leukemia, 11, 1904-1904 (1997)
Assessment of the sensitizing potential of processed peanut proteins in Brown Norway rats: roasting does not enhance allergenicity.
Kroghsbo S et al.
PLoS ONE, 9, e96475-e96475 (2014)
Formalin-inactivated bovine RSV vaccine enhances a Th2 mediated immune response in infected cattle.
Kalina WV et al.
Vaccine, 22, 1465-1465 (2004)
Amino Acids, Peptides and Proteins in Organic Chemistry (2013)
Westermeier R
Electrophoresis in Practice: A Guide to Methods and Applications of DNA and Protein Separations (2016)
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