≥95% (HPLC), from plant

5,5′-Diallyl-2,2′-biphenyldiol, 2,2′-Bichavicol
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
MDL number:
PubChem Substance ID:

Quality Level

biological source



≥95% (HPLC)


ethanol: soluble 1 mg/mL
methanol: soluble 1.5 mg/mL

Mode of action

cell membrane | interferes

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

storage temp.


SMILES string




InChI key


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10 mg in glass bottle

Biochem/physiol Actions

Magnolol is a bioactive plant component isolated from the root and stem bark of Magnolia officinalis with antifungal, antibacterial and antioxidant effects. Magnolol also demonstrates anti-inflammatory activity by interferring with NF-κB signaling. It also appears to have anti-inflammatory properties related to vascular disorders such as atherosclerosis due to its ability to inhibit IL-6-induced STAT3 activation.

Signal Word


Hazard Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


UN 3077 9 / PGIII

WGK Germany


Jianhong Zhang et al.
BioMed research international, 2019, 1847130-1847130 (2019-06-27)
Over years, various biological constituents are isolated from Traditional Chinese Medicine and confirmed to show multifunctional activities. Magnolol, a hydroxylated biphenyl natural compound isolated from Magnolia officinalis, has been extensively documented and shows a range of biological activities. Many signaling...
Yongtao Bai et al.
Steroids, 135, 73-78 (2018-03-21)
Evidence showed that the stress hormone corticosterone (CORT) injection resulted in dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis implicated in major depressive disorder. Magnolol, main constituent identified in the barks of Magnolia officinalis, exerted antidepressant effects in a rat model of...
Rajendra Karki et al.
Experimental cell research, 319(20), 3238-3250 (2013-08-03)
Increased proliferation and migration of vascular smooth muscle cells (VSMCs) contribute importantly to the formation of both atherosclerotic and restenotic lesions. The objective of this study was to investigate the effect of magnolol on VSMC migration. The proteolytic activity of...
Abhishek Manoj Ranaware et al.
International journal of molecular sciences, 19(8) (2018-08-15)
The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will...
Jie Cheng et al.
International immunopharmacology, 59, 61-67 (2018-04-09)
Magnolol, the main constituent of Magnolia officinalis, has been shown to produce antidepressant-like effect in rodents. Growing evidence shows that neuroinflammation, oxidative stress and neuroendocrine contribute to the pathogenesis of major depression. Here, the aim of this present study was...
Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.
Read More
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
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