M3671

Sigma-Aldrich

MES

low moisture content, ≥99% (titration)

Synonym(s):
4-Morpholineethanesulfonic acid, 2-(N-Morpholino)ethanesulfonic acid
Empirical Formula (Hill Notation):
C6H13NO4S
CAS Number:
Molecular Weight:
195.24
Beilstein/REAXYS Number:
141319
EC Number:
MDL number:
eCl@ss:
32129211
PubChem Substance ID:
NACRES:
NA.25

Quality Level

assay

≥99% (titration)

form

powder

impurities

≤1.0% water

pH

2.5-4 (25 °C, 97.6 g/L)

useful pH range

5.5 - 6.7

pKa 

6.1

Featured Industry

Diagnostic Assay Manufacturing

SMILES string

OS(=O)(=O)CCN1CCOCC1

InChI

1S/C6H13NO4S/c8-12(9,10)6-3-7-1-4-11-5-2-7/h1-6H2,(H,8,9,10)

InChI key

SXGZJKUKBWWHRA-UHFFFAOYSA-N

Related Categories

General description

MES is one of the Good′s buffers, the most extensively used biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring. It does not form complexes with majority of the metals used in environmental and biological studies. It is easily soluble in water and has minimum lipid solubility, making it impermeable to membranes.

Application

MES has been used as a component of the elution buffer used to elute plasma from α2-macroglobulin affinity column. It has been used as an activation buffer during antibody conjugation to microparticles. MES has been used in the functionalization of microchannels during the creation of microfluidic-integrated surface plasmon resonance (SPR) platform for pathogen detection.

Packaging

50, 250 g in poly bottle
1 kg in poly bottle

Quality

Low moisture

Other Notes

Easily compare specifications for MES products with the MES specification table.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What does low moisture content mean in the description of Product M3671, MES - low moisture?

    The amount of water/moisture for MES (M3671) is tested by Karl Fisher and meets a specification of less than 1%. The other MES Hydrates offered have a specification of less than 9%.

  4. What is the solubility of Product M3671, MES - low moisture?

    We test the solubility of Prod. No. M3671 at 20 grams in 80 mL of water. A clear, colorless solution is obtained. This concentration is not necessarily the upper solubility limit of MES in water.

  5. What is the pH of a solution of Product M3671, MES - low moisture?

    The pH of a 0.5 M solution in water should be between 2.5 and 4.0.

  6. Is Product M3671, MES - low moisture, autoclavable?

    Autoclaving is not recommended for any sulfonic acid buffer solution. Sterilization of a MES buffer solution can be accomplished by filtering it through a 0.2 micron filter.

  7. How does one prepare a buffer using Product M3671, MES - low moisture, free acid?

    A buffer using MES free acid can be prepared by titrating the free acid with sodium hydroxide to the desired pH. Alternatively, volumes of equimolar MES free acid and sodium MES can be mixed to attain the desired pH.

  8. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  9. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Sensitive Mie scattering immunoagglutination assay of porcine reproductive and respiratory syndrome virus (PRRSV) from lung tissue samples in a microfluidic chip
Song, Jae-Young, et al.
J. Virol. Methods, 178, 31-38 (2011)
Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-? is an early biomarker for mild cognitive impairment preceding Alzheimer's disease.
Sagare, Abhay P., et al.
Journal of Alzheimer'S Disease, 24 (1), 25-34 (2011)
Portable microfluidic integrated plasmonic platform for pathogen detection
Tokel, Onur, et al.
Scientific Reports, 2015, 9152-9152 null
"(Un) suitability of the use of pH buffers in biological, biochemical and environmental studies and their interaction with metal ions-a review.
Ferreira, Carlos MH, et al.
Royal Society of Chemistry Advances, 5 (39), 30989-31003 (2015)
Sensitive Mie scattering immunoagglutination assay of porcine reproductive and respiratory syndrome virus (PRRSV) from lung tissue samples in a microfluidic chip.
Song JY, Lee CH, Choi EJ, Kim K, et al.
J. Virol. Methods, 178, 31-38 (2011)
Protocols
Overview of polyacrylamide gel chemistry and detailed instructions for hand-casting polyacrylamide gels using TurboMix™ Bis-Tris Gel Casting Kits
Read More
Technical article page on -US EPA Method 8015 (modified): GC Analysis of Gasoline Range Organics (GRO) on Equity®-1 after Purge & Trap using "M" Trap
Read More

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.