SAB1305567

Sigma-Aldrich

MONOCLONAL ANTI-BETA-ACTIN antibody produced in mouse

clone 8H10D10, crude ascites, buffered aqueous solution

Synonym(s):
ACTB, Actin, cytoplasmic 1, Actin, cytoplasmic 1, N-terminally processed, Beta-actin
NACRES:
NA.41

Quality Level

biological source

mouse

antibody form

crude ascites

antibody product type

primary antibodies

clone

8H10D10, monoclonal

form

buffered aqueous solution

mol wt

41737 Da

species reactivity

human

application(s)

immunohistochemistry: 1:10-1:50
western blot: 1:5000-1:20000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ACTB(60)

General description

ACTB (actin β) gene codes for β-actin. It is a cytoskeletal housekeeping protein. It is present in the cytoplasm. This gene is located on human chromosome 7p22.1.

Application

MONOCLONAL ANTI-BETA-ACTIN antibody has been used in western blotting.

Biochem/physiol Actions

β-Actin modulates cell growth, migration and the G-actin pool. Mutations in ACTB leads to pleiotropic developmental disorder.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Lisa Mutschelknaus et al.
Scientific reports, 7(1), 12423-12423 (2017-10-01)
Radiation is a highly efficient therapy in squamous head and neck carcinoma (HNSCC) treatment. However, local recurrence and metastasis are common complications. Recent evidence shows that cancer-cell-derived exosomes modify tumour cell movement and metastasis. In this study, we link radiation-induced...
Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells.
Mutschelknaus L, et al.
Scientific Reports, 7(1), 12423-12423 (2017)
Lisa Mutschelknaus et al.
PloS one, 11(3), e0152213-e0152213 (2016-03-24)
Exosomes are nanometer-sized extracellular vesicles that are believed to function as intercellular communicators. Here, we report that exosomes are able to modify the radiation response of the head and neck cancer cell lines BHY and FaDu. Exosomes were isolated from...
Ravindra Pramod Deshpande et al.
The International journal of neuroscience, 129(2), 171-178 (2018-08-28)
Astrocytoma represents most noted malignancy of the brain. The overall survival rate of patients with progressive form remains dismal despite of the present clinical advancements. Search for biomarkers can open new avenues of therapeutic measures to curb the progressive astrocytic...
Xinjun Lin et al.
Experimental and therapeutic medicine, 16(1), 204-212 (2018-06-14)
The present study aimed to evaluate the impact of dendrobium mixture (DMix) on the gene and protein expression of insulin signaling pathway-associated factors in the livers of diabetic rats. The molecular mechanisms by which DMix inhibits gluconeogenesis were also investigated....

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