Showing 1-30 of 280 results for "09735"
Ji Ye Lee et al.
Bioresource technology, 132, 84-90 (2013-02-12)
The objective of this work was to investigate the feasibility of acid-catalyzed hydrothermal fractionation for maximum solubilization of the hemicellulosic portion of three agricultural residues. The fractionation conditions converted into combined severity factor (CS) in the range of 1.2-2.9. The...
Gang Ahn et al.
Biomedical chromatography : BMC, 28(7), 919-922 (2014-01-25)
A simple, fast and reliable high-performance liquid chromatography-triple quadrupole mass spectrometry method (HPLC-MS/MS method) was developed, validated and used for the simultaneous quantification of irinotecan and 7-ethyl-10-hydroxycamptothecin (SN38) in heparinized mouse plasma. Camptothecin was used as the internal standard. A...
Yang Ni et al.
Journal of pharmaceutical and biomedical analysis, 107, 444-449 (2015-02-11)
A new method for simultaneous determination of phentermine and topiramate by liquid chromatography/electrospray tandem mass spectrometry (LC/MS/MS) operated in positive and negative ionization switching modes was developed and validated. Protein precipitation with acetonitrile was selected for sample preparation. Analyses were...
Shuang-Qing Zhang
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 24-28 (2014-12-23)
Icaritin (ICT), a bioactive metabolite of prenylflavonoids from genus Epimedium, has displayed potential benefits for the treatment of osteoporosis, prostate cancer, liver cancer, renal cancer and breast cancer. To investigate the quantity of ICT in bones in vivo, a simple...
João Cleverson Gasparetto et al.
PloS one, 10(3), e0118922-e0118922 (2015-03-11)
For decades guaco species have been empirically used for the treatment of respiratory diseases. However, studies have shown that the toxic and therapeutic effects of the main guaco metabolites are dose-dependent, and none clinical study was done to evaluate the...
Laurent Imbert et al.
Journal of analytical toxicology, 38(9), 676-680 (2014-09-05)
A liquid chromatography coupled with electrospray tandem mass spectrometry method was developed for the analysis of ethylene glycol, diethylene glycol, triethylene glycol, 1,4-butanediol, 1,2-butanediol, 2,3-butanediol, 1,2-propanediol and 1,3-propanediol, in serum after a Schotten-Baumann derivatization by benzoyl chloride. Usual validation parameters...
Coleman T Turgeon et al.
Molecular genetics and metabolism, 114(1), 46-50 (2014-12-08)
Pre-symptomatic hematopoietic stem cell transplantation is essential to achieve best possible outcomes for patients with the childhood cerebral form of X-linked adrenoleukodystrophy (X-ALD). We describe a high-throughput method for measurement of C20-C26 lysophosphatidylcholines (LPCs) and biochemical diagnosis of X-ALD using...
Yana Ryzhmanova et al.
Extremophiles : life under extreme conditions, 17(5), 851-859 (2013-07-25)
New strains of sulfate-reducing bacteria were isolated from two alkaline brackish lakes located in the Siberian region of Russia, namely in the Southern Transbaikalia, Buriatia. The article presents data describing morphology, physiology, and biochemical characteristics of the isolated strains. These...
Tanya Q Shang et al.
Journal of pharmaceutical sciences, 103(7), 1967-1978 (2014-05-21)
A highly robust hydrophilic interaction liquid chromatography (HILIC) method that involves both fluorescence and mass spectrometric detection was developed for profiling and characterizing enzymatically released and 2-aminobenzamide (2-AB)-derivatized mAb N-glycans. Online HILIC/mass spectrometry (MS) with a quadrupole time-of-flight mass spectrometer...
J-F Li et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 33(10), 1725-1732 (2014-05-09)
Hepatic steatosis affects disease progression in patients with chronic hepatitis C virus (HCV) infection. We investigated the plasma sphingolipid profile in patients with chronic hepatitis C (CHC) and whether there was an association between HCV-related steatosis and plasma sphingolipids. We...
Prem K Gupta et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(4), 534-552 (2015-01-23)
The disposition and metabolism of hydrastine was investigated in 11 healthy subjects following an oral dose of 2.7 g of goldenseal supplement containing 78 mg of hydrastine. Serial blood samples were collected for 48 hours, and urine was collected for...
Jae Won Lee et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 966, 193-199 (2014-02-21)
In this study, supercritical fluid chromatography (SFC) coupled with triple quadrupole mass spectrometry was applied to the profiling of several regioisomeric triacylglycerols (TAGs). SFC conditions (column, flow rate, modifier) were optimized for the effective separation of TAGs. In the column...
Michael Lever et al.
Cardiovascular drugs and therapy, 28(5), 459-468 (2014-07-26)
Betaine deficiency is a probable cardiovascular risk factor and a cause of elevated homocysteine. Urinary betaine excretion is increased by fibrate treatment, and is also often elevated in diabetes. Does fibrate further increase betaine excretion in diabetes, and does it...
Sifei Han et al.
Pharmaceutical research, 32(5), 1830-1844 (2014-12-03)
Recent studies have demonstrated the potential for a triglyceride (TG) mimetic prodrug to promote the delivery of mycophenolic acid (MPA) to the lymphatic system. Here, the metabolic pathways that facilitate the lymphatic transport of the TG prodrug (1,3-dipalmitoyl-2-mycophenoloyl glycerol, 2-MPA-TG)...
Ramesh Boinpally et al.
Clinical therapeutics, 36(11), 1638-1649 (2014-09-23)
Vilazodone is a serotonin reuptake inhibitor and 5-HT1A partial agonist approved for the treatment of major depressive disorder in adults. Vilazodone seems to be metabolized primarily by the cytochrome P-450 (CYP) 3A4 isozyme and non-CYP-mediated pathways; concomitant use of drugs...
Weronika Hewelt-Belka et al.
Journal of chromatography. A, 1362, 62-74 (2014-08-28)
Staphylococcus aureus is a common pathogen known to cause relatively minor infections as well as severe disorders in humans. Although there is fair amount of published data concerning various aspects of its biology, epidemiology, genetics, etc., there is still a...
Ying Zhou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 976-977, 78-83 (2014-12-09)
A robust and validated method based on ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) has been developed for the simultaneous determination of remimazolam, which is a new chemical entity, and its major carboxylic acid metabolite (M1) in human...
Aleksander Salwiński et al.
Rapid communications in mass spectrometry : RCM, 28(18), 1957-1963 (2014-08-19)
Tyrosinase-coupled magnetic particles (EMPs) were used to demonstrate that resorcinol-containing tyrosinase inhibitors are oxidised by tyrosinase only in the presence of the enzyme's classic substrate. This shows the potential for the application of EMPs as a non-organic matrix for monitoring...
Xin Xiong et al.
Biomedical chromatography : BMC, 29(2), 268-274 (2014-06-24)
A high-throughout bioanalytical method based on salting-out-assisted liquid/liquid extraction (SALLE) method with acetonitrile and mass spectrometry-compatible salts followed by LC-MS/MS analysis of trimetazidine in rat plasma is presented. It required only 50 μL of plasma and allows the use of minimal...
Aljona Saleh et al.
Journal of pharmaceutical and biomedical analysis, 104, 1-11 (2014-12-03)
MTH1 is a protein that is required for cancer cell survival and is overexpressed in cancer cells. TH588 and TH287 are two new compounds that inhibit the MTH1 protein. The inhibitors were tested in pharmacokinetic studies on mice. A bioanalytical...
Long Yuan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 60-68 (2014-08-26)
A sensitive, accurate and rugged UHPLC-MS/MS method was developed and validated for the quantitation of Epothilone D (EpoD), a microtubule stabilizer in development for treatment of Alzeimer's disease, in rat plasma. The ester group in EpoD can be hydrolyzed by...
Nathaniel W Snyder et al.
Journal of lipid research, 56(1), 142-150 (2014-11-27)
Metabolism of propionate involves the activated acyl-thioester propionyl-CoA intermediate. We employed LC-MS/MS, LC-selected reaction monitoring/MS, and LC-high-resolution MS to investigate metabolism of propionate to acyl-CoA intermediates. We discovered that propionyl-CoA can serve as a precursor to the direct formation of...
Sheng Feng et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 915-916, 28-32 (2013-01-15)
This paper described a sensitive and rapid method based on ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) for the determination of phenylephrine in human plasma. Plasma samples were pre-purified by solid-phase extraction (SPE). The chromatographic separation was achieved...
Anne Mette Lerbech et al.
PloS one, 9(12), e113055-e113055 (2014-12-03)
Development of antimicrobial resistance has been assigned to excess and misuse of antimicrobial agents. Staphylococci are part of the normal flora but are also potential pathogens that have become essentially resistant to many known antibiotics. Resistances in coagulase negative staphylococci...
Lucie Nováková et al.
Analytica chimica acta, 853, 637-646 (2014-12-04)
The conditions for the analysis of selected doping substances by UHPSFC-MS/MS were optimized to ensure suitable peak shapes and maximized MS responses. A representative mixture of 31 acidic and basic doping agents was analyzed, in both ESI+ and ESI- modes....
Ping Du et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 28-35 (2014-07-27)
Docetaxel lipid microsphere (DT-LM) is a novel formulation of docetaxel without Tween-80. A sensitive, robust and reproducible ultrafiltration (UF) followed by UPLC-MS/MS method was developed and validated for the quantification of unbound docetaxel in human plasma using paclitaxel as IS....
Niclas Stephanson et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 189-196 (2015-02-18)
A mass spectrometric method for drugs of abuse testing in exhaled breath employing a sampling device collecting aerosol particles was developed and applied in routine use. Analytes covered were amphetamine, methamphetamine, 6-acetylmorphine, morphine, cocaine, benzoylecgonine, diazepam, oxazepam and tetrahydrocannabinol. The...
Andrew J S Hanneman et al.
Journal of pharmaceutical sciences, 103(2), 400-408 (2013-12-05)
Glycosylation is a critical parameter used to evaluate protein quality and consistency. N-linked glycan profiling is fundamental to the support of biotherapeutic protein manufacturing from early stage process development through drug product commercialization. Sialylated glycans impact the serum half-life of...
Jésus Raya et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 227, 93-102 (2013-01-15)
A simple multiple-contact cross-polarization (CP) scheme is applied to a powder sample of ferrocene and β-calcium formate under static and magic-angle spinning (MAS) conditions. The method is described analytically through the density matrix formalism. We show that multiple equilibrations-re-equilibrations with...
Gordon C C Yang et al.
Journal of hazardous materials, 277, 53-61 (2014-04-08)
This study monitored the occurrence and removal efficiencies of 8 phthalate esters (PAEs) and 13 pharmaceuticals present in the drinking water of Kaohsiung City, Taiwan. The simultaneous electrocoagulation and electrofiltration (EC/EF) process was used to remove the contaminants. To this...

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