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Annexin A2 is involved in activation of extracellular signal-regulated kinase upon endothelin-1 stimulation.

Biochemical and biophysical research communications (2019-02-18)
Yuichi Mazaki, Tsunehito Higashi, Takahiro Horinouchi, Soichi Miwa
ABSTRACT

The overexpression of endothelin (ET)-1 or ET receptors (ETRs) is related to initiation and progression of tumor. In cancer cells, ET-1 activates various signaling pathways, including mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase C through ETRs, although the mechanisms by which ET-1 activates these signaling pathways remain uncertain. Here, we found that ETRs interacted with annexin A2, which is overexpressed in various cancers. Annexin A2 bound to ET type A receptor and ET type B receptor. Upon ET-1 stimulation, serine phosphorylation of annexin A2 increased, while there is no change in tyrosine phosphorylation of annexin A2. On the other hand, annexin A2 silencing suppressed activation of ERK upon ET-1 stimulation. These results suggest that interaction of ETRs and annexin A2 may play important roles in activation of extracellular signal-regulated kinase upon ET-1 stimulation.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
O-Phospho-L-tyrosine
Sigma-Aldrich
MISSION® esiRNA, targeting human ANXA2

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