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Validation of a spectrophotometric assay method for bisoprolol using picric acid.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi (2013-12-18)
Alina-Diana Panainte, Nela Bibire, Gladiola Tântaru, M Apostu, Mădălina Vieriu
ABSTRACT

Bisoprolol is a drug belonging to beta blockers drugs used primarily for the treatment of cardiovascular diseases. A spectrophotometric method for quantitative determination of bisoprolol was developed based on the formation of a complex combination between bisoprolol and picric acid. The complex combination of bisoprolol and picric acid has a maximum absorbance peak at 420 nm. Optimum working conditions were established and the method was validated. The method presented a good linearity in the concentration range 5-120 microg/ml (regression coefficient r2 = 0.9992). The RSD for the precision of the method was 1.74 and for the intermediate precision 1.43, and recovery values ranged between 98.25-101.48%. The proposed and validated spectrophotometric method for the determination of bisoprolol is simple and cost effective.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Picric acid, moistened with water, ≥98%

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