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Samarium lexidronam (153Sm-EDTMP): skeletal radiation for osteoblastic bone metastases and osteosarcoma.

Expert review of anticancer therapy (2007-11-21)
Pete Anderson, Rodolfo Nuñez
ABSTRACT

Radiation therapy can be an effective means to treat bone metastases, which occur in more than 50% of cancer patients. (153)Samarium lexidronam ((153)Sm-EDTMP; Quadramet, Cytogen) is a radiopharmaceutical designed for deposition into bone metastases. Bone scans can identify patients that may benefit from targeted radiation therapy with (153)Sm-EDTMP. As an unsealed source of radiation therapy, (153)Sm-EDTMP is simple to administer: 1 mCi/kg is given in a similar fashion to a bone scan injection ((99m)Tc-MDP bone scan injection is given at 0.2-0.35 mCi/kg. Therefore, both are administered intravenously. However, the radiation-absorbed dose and radiopharmaceutical energy are different). Nevertheless, despite simplicity of administration, (153)Sm-EDTMP is underutilized for improving cancer pain in the skeleton. Repeated cycles and combined treatment with other modalities such as bisphosphonates, chemotherapy and/or external beam radiation are possible. (153)Sm-EDTMP combined with bisphosphonates, chemotherapy and/or radiation may provide better palliation of bone metastases and also in bone-forming tumors (osteosarcoma). Encouraging experience using high-dose (153)Sm-EDTMP for total marrow irradiation in hematologic malignancies involving the bones (e.g., myeloma or acute leukemia) is also reviewed.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Samarium, −40 mesh, 99% trace rare earth metals basis
Sigma-Aldrich
Samarium, ingot, 99.9% trace rare earth metals basis
Samarium, foil, 25x25mm, thickness 0.1mm, as rolled, 99%
Samarium, foil, 25x25mm, thickness 0.25mm, as rolled, 99%
Samarium, foil, 50x50mm, thickness 0.1mm, as rolled, 99%
Samarium, foil, 50x50mm, thickness 0.25mm, as rolled, 99%
Samarium, foil, not light tested, 25x25mm, thickness 0.005mm, as rolled, 99%
Samarium, foil, not light tested, 25x25mm, thickness 0.025mm, as rolled, 99%
Samarium, foil, not light tested, 50x50mm, thickness 0.025mm, as rolled, 99%
Samarium, rod, 100mm, diameter 6.35mm, cast, 99%
Samarium, rod, 50mm, diameter 6.35mm, cast, 99%
Sigma-Aldrich
Samarium, foil, thickness 1 mm, 99.9% trace rare earth metals basis

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