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700001P

Avanti

DC-Cholesterol HCl

Avanti Polar Lipids 700001P, powder

Synonym(s):
3β-[N-(N′,N′-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride
Empirical Formula (Hill Notation):
C32H57N2O2Cl
CAS Number:
Molecular Weight:
537.26
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (700001P-1g)
pkg of 1 × 200 mg (700001P-200mg)
pkg of 1 × 25 mg (700001P-25mg)
pkg of 1 × 500 mg (700001P-500mg)

manufacturer/tradename

Avanti Polar Lipids 700001P

application(s)

vaccine development

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](C1)(OC(NCC[N+](C)([H])C)=O)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](C)CCCC(C)C.[Cl-]

InChI

1S/C32H56N2O2.ClH/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5;/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35);1H

InChI key

ISXSJGHXHUZXNF-UHFFFAOYSA-N

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DC-Cholesterol HCl Avanti Polar Lipids 700001P, powder

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form

powder

packaging

pkg of 1 × 1 g (700001P-1g), pkg of 1 × 200 mg (700001P-200mg), pkg of 1 × 25 mg (700001P-25mg), pkg of 1 × 500 mg (700001P-500mg)

packaging

pkg of 1 × 5 mg (700002P-5mg)

packaging

pkg of 1 × 25 mg (700054P-25mg), pkg of 1 × 5 mg (700054P-5mg)

packaging

pkg of 1 × 1 mg (700061P-1mg), pkg of 1 × 5 mg (700061P-5mg)

manufacturer/tradename

Avanti Polar Lipids 700001P

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

DC-Cholesterol HCl is a cholesterol derivative and a cationic lipid with a head group and linker moiety.
DC-Cholesterol HCl is a sterol-based transfection reagent.

Application

DC-Cholesterol HCl is suitable:
  • for the preparation of ultrasound cationic microbubbles
  • to prepare liposomes
  • for the preparation of L-glutathione (GSH), loaded proliposomes

DC-Cholesterol HCl may be used in the preparation of colloidal dispersions for transmission electron microscopy studies. It may also be used in liposome preparation for assessing hexokinase activity, poly (lactic-coglycolicacid) loading and in mRNA transfection studies.

Biochem/physiol Actions

DC-Cholesterol is an effective transfection agent and a liposome reagent. Liposome of DC-Cholesterol with dioleoylphosphatidylethanolamine (DOPE) are efficient for DNA transfection. It imparts positive surface charge to the microbubbles for ultra sound based transfection of clustered regularly interspaced short palindromic repeats (CRISPRs).
DC-cholesterol is a cationic lipid, known to be the most efficient in gene transfection study.

Packaging

20 mL Clear Glass Screw Cap Vial (700001P-1g)
20 mL Clear Glass Screw Cap Vial (700001P-500mg)
5 mL Amber Glass Screw Cap Vial (700001P-200mg)
5 mL Amber Glass Screw Cap Vial (700001P-25mg)

also commonly purchased with this product

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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