791300P

18:0 PE-DTPA

Avanti Polar Lipids 791300P, powder

• Synonym(s): 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (ammonium salt)
• Empirical Formula (Hill Notation): C₅₅H₁₁₈N₉O₁₇P
• CAS Number: 1585969-98-7
• Molecular Weight: 1208.55
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 5 mg (791300P-5mg)
• manufacturer/tradename: Avanti Polar Lipids 791300P
• shipped in: dry ice
• storage temp.: −20°C

Description

General description

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (18:0 PE-DTPA) comprises synthetic phospholipid derivative of ethanolamine.

This chelate is used for preparing MRI contrast agents.

Application

18:0 PE-DTPA (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (ammonium salt)) has been used to chelate liposome-based cationic adjuvant formulation (CAF01). It has also been used in the liposome preparation for imaging studies

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (18:0 PE-DTPA) or PE-DTPA binding and interaction with the Toll-like receptor-2 regulates immune response . PE-DTPA acts as a lipopolysaccharide antagonist and elicits rescue functionality in sepsis by blocking nuclear factor κ -light-chain-enhancer of activated B cells based transcription.

Packaging

5 mL Amber Glass Screw Cap Vial (791300P-5mg)

Safety Information

• Storage Class Code: 11 - Combustible Solids