Merck
All Photos(2)

Documents

810262P

Avanti

C11 TopFluor® Ceramide

N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosine, powder

Sign Into View Organizational & Contract Pricing

Select a Size

Change View

Select a Size

Change View
Synonym(s):
N-[11-(TopFluor)undecanoyl]-D-erythro-sphingosine
Empirical Formula (Hill Notation):
C42H70N3O3F2
CAS Number:
Molecular Weight:
703.02
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 250 μg (810262P-250ug)

manufacturer/tradename

Avanti Polar Lipids 810262P

shipped in

dry ice

storage temp.

−20°C

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
810266P810267P810270P
C11 TopFluor® Ceramide N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosine, powder

Avanti

810262P

C11 TopFluor® Ceramide

form

powder

form

powder

form

powder

form

powder

packaging

pkg of 1 × 250 μg (810262P-250ug)

packaging

pkg of 1 × 250 μg (810266P-250ug)

packaging

pkg of 1 × 250 μg (810267P-250ug)

packaging

pkg of 1 × 250 μg (810270P-250ug)

manufacturer/tradename

Avanti Polar Lipids 810262P

manufacturer/tradename

Avanti Polar Lipids 810266P

manufacturer/tradename

Avanti Polar Lipids 810267P

manufacturer/tradename

Avanti Polar Lipids 810270P

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

Ceramide, a bioactive sphingolipid belongs to the sphingolipid family of cell lipids. This pore-forming member is insoluble in water. It is a hygroscopic and light sensitive lipid.

Application

C11 TopFluor® Ceramide may be used:
  • in the ceramide and B-cell lymphoma-extra-large (Bcl-xL) binding studies to study the effect on ceramide channel formation
  • as a tracer in confocal microscopy to treat T84 cells in order to study its localization in sphingomyelinase (SMase)-induced F-actin structures
  • to study its effect on the migration of pancreatic cancer stem cells (PCSC) using confocal microscopy

Biochem/physiol Actions

Ceramide is known to participate in apoptosis, mediated by mitochondria. Ceramide channels plays a key role in the onset of apoptosis in vivo.

Packaging

5 mL Amber Glass Screw Cap Vial (810262P-250ug)

Legal Information

TopFluor is a registered trademark of Avanti Polar Lipids, Inc.

Storage Class Code

11 - Combustible Solids


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion
Saslowsky DE, et al.
Molecular Biology of the Cell, 27(7), 1120-1130 (2016)
Ceramide Channels: Destabilization by Bcl-xL and Role in Apoptosis
Chang KT, et al.
Biochimica et Biophysica Acta, 1848(10 0 0), 2374-2374 (2015)
Pancreatic ductal adenocarcinoma cell secreted extracellular vesicles containing ceramide-1-phosphate promote pancreatic cancer stem cell motility
Kuc N, et al.
Biochemical Pharmacology, 156, 458-466 (2018)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service