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890705C

Avanti

16:0-18:1 EPC (Cl Salt)

Avanti Polar Lipids 890705C

Synonym(s):
1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (chloride salt)
Empirical Formula (Hill Notation):
C44H87NO8PCl
CAS Number:
Molecular Weight:
824.59
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 1 mL (890705C-10mg)
pkg of 1 × 2.5 mL (890705C-25mg)

manufacturer/tradename

Avanti Polar Lipids 890705C

concentration

10 mg/mL (890705C-10mg)
10 mg/mL (890705C-25mg)

lipid type

transfection
cationic lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)OCC.[Cl-]

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This Item
890705P890895C890895P
16:0-18:1 EPC (Cl Salt) Avanti Polar Lipids 890705C

Avanti

890705C

16:0-18:1 EPC (Cl Salt)

16:0-18:1 EPC (Cl Salt) Avanti Polar Lipids 890705P, powder

Avanti

890705P

16:0-18:1 EPC (Cl Salt)

18:1 TAP (DOTAP, MS Salt) Avanti Polar Lipids 890895C

Avanti

890895C

18:1 TAP (DOTAP, MS Salt)

18:1 TAP (DOTAP, MS Salt) Avanti Polar Lipids 890895P, powder

Avanti

890895P

18:1 TAP (DOTAP, MS Salt)

packaging

pkg of 1 × 1 mL (890705C-10mg), pkg of 1 × 2.5 mL (890705C-25mg)

packaging

pkg of 1 × 10 mg (890705P-10mg), pkg of 1 × 25 mg (890705P-25mg)

packaging

pkg of 1 × 2.5 mL (890895C-25mg), pkg of 2 × 4 mL (890895C-200mg)

packaging

pkg of 2 × 100 mg (890895P-200mg), pkg of 1 × 25 mg (890895P-25mg)

manufacturer/tradename

Avanti Polar Lipids 890705C

manufacturer/tradename

Avanti Polar Lipids 890705P

manufacturer/tradename

Avanti Polar Lipids 890895C

manufacturer/tradename

Avanti Polar Lipids 890895P

concentration

10 mg/mL (890705C-10mg), 10 mg/mL (890705C-25mg)

concentration

-

concentration

10 mg/mL (890895C-25mg), 25 mg/mL (890895C-200mg)

concentration

-

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (16:0-18:1 EPC) is cationic lipid containing an ethyl group attached to the phosphate moiety through an ester bond and has a choline headgroup.

Application

1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (chloride salt) (16:0-18:1 EPC (Cl Salt)) might be used:
  • as a cationic lipid to explore the change in organization and dynamics of a membrane-bound fluorescent probe in host membranes of varying charge
  • in the preparation of small unilamellar cationic liposomes
  • in a novel albumin-associated lipoplex formulation to evaluate the antitumoral efficacy of immuno-gene therapy and “suicide” gene therapy

Biochem/physiol Actions

1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (16:0-18:1 EPC) is a potential transfection agent, which is also like the natural lipids.

Packaging

5 mL Clear Glass Sealed Ampule (890705C-10mg)
5 mL Clear Glass Sealed Ampule (890705C-25mg)

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

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Marta Passadouro et al.
International journal of nanomedicine, 9, 3203-3217 (2014-07-26)
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and mortal cancer, characterized by a set of known mutations, invasive features, and aberrant microRNA expression that have been associated with hallmark malignant properties of PDAC. The lack of effective PDAC treatment
Modulation of fluorophore environment in host membranes of varying charge
Kelkar DA, et al.
Journal of Fluorescence, 13(6), 459-466 (2003)
H Faneca et al.
Biochimica et biophysica acta, 1768(5), 1093-1102 (2007-02-14)
In the present work, we used a novel albumin-associated lipoplex formulation, containing the cationic lipid 1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (EPOPC) and cholesterol (Chol), to evaluate the antitumoral efficacy of two gene therapy strategies: immuno-gene therapy, mediated by IL-12 gene expression, and "suicide" gene
Wei Zong et al.
Langmuir : the ACS journal of surfaces and colloids, 34(23), 6874-6886 (2018-05-20)
The success of nanoparticulate formulations in drug delivery depends on various aspects including their toxicity, internalization, and intracellular location. Vesicular assemblies consisting of phospholipids and amphiphilic block copolymers are an emerging platform, which combines the benefits from liposomes and polymersomes
Li Wang et al.
Molecular pharmaceutics, 4(4), 615-623 (2007-04-06)
To date, the primary approach to improving the transfection properties of cationic lipids has been the synthesis of new kinds of cationic amphipaths. Recently, however, it was found that combining two cationic lipid derivatives having the same head group but

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