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Synonym(s):
Ethyl acetoacetate, EAA, Acetoacetic acid ethyl ester
Empirical Formula (Hill Notation):
C6H10O3
CAS Number:
Molecular Weight:
130.14
MDL number:
UNSPSC Code:
12352108
EC Index Number:
205-516-1
NACRES:
NA.22
Recommended Products
vapor pressure
0.26 hPa ( 20 °C)
Quality Level
Assay
≥98.0% (GC)
form
liquid
autoignition temp.
350 °C
potency
3980 mg/kg LD50, oral (Rat)
>5000 mg/kg LD50, skin (Rabbit)
expl. lim.
1.0-54 % (v/v)
pH
4.0 (20 °C, 110 g/L in H2O)
mp
-53.3 °C
transition temp
flash point 73.5 °C
solubility
130.3 g/L
density
1.03 g/cm3 at 20 °C
storage temp.
2-30°C
InChI
1S/C6H10O3/c1-3-9-6(8)4-5(2)7/h3-4H2,1-2H3
InChI key
XYIBRDXRRQCHLP-UHFFFAOYSA-N
Application
Ethyl acetoacetate can be used as a reactant to synthesize:
It can be also utilized as a reactant in the transesterification and asymmetric hydrogenation reactions to produce valuable products.
- 7-hydroxycoumarin derivatives via Pechmann condensation reaction with 1,3-dihydroxybenzene in the presence of acid catalysts.
- 2,6-disubstituted piperidine alkaloid, (−)-pinidinone via stereoselective α-aminoallylation followed by Grubbs′ olefin cross-metathesis reaction.
- Michael addition products via Michael addition reaction with chalcones and azachalcones in the presence of a base catalyst.
- α, β-unsaturated carbonyl compounds via Knoevenagel condensation reaction with glyceraldehyde acetonide in the presence of a base catalyst.
It can be also utilized as a reactant in the transesterification and asymmetric hydrogenation reactions to produce valuable products.
Analysis Note
Assay (GC, area%): ≥ 98.0 % (a/a)
Density (d 20 °C/ 4 °C): 1.028 - 1.030
Identity (IR): passes test
Density (d 20 °C/ 4 °C): 1.028 - 1.030
Identity (IR): passes test
WGK
WGK 1
Flash Point(F)
164.3 °F
Flash Point(C)
73.5 °C
Certificates of Analysis (COA)
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