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33114

Sigma-Aldrich

Citric acid monohydrate

puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., buffer substance, 99.5-102%

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Synonym(s):
2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate
Linear Formula:
HOC(COOH)(CH2COOH)2 · H2O
CAS Number:
Molecular Weight:
210.14
Beilstein:
4018641
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

grade

ACS reagent
puriss. p.a.

Quality Level

Agency

USP/NF
reag. ISO
reag. Ph. Eur.

Assay

99.5-100.5% (calc. on anhydrous substance)
99.5-102%

form

solid

impurities

≤0.005% insolubles in water
≤2 ppm heavy metals (as Pb)
7.5-9.0% water (Karl Fischer)

ign. residue

≤0.01% (as SO4)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

anion traces

chloride (Cl-): ≤5 mg/kg
oxalate (C2O42-): ≤50 ppm
phosphate (PO43-): ≤10 mg/kg
sulfate (SO42-): ≤20 ppm

cation traces

Ca: ≤50 mg/kg
Cu: ≤5 mg/kg
Fe: ≤3 ppm
Pb: ≤2 ppm
Zn: ≤5 mg/kg

suitability

complies for appearance of solution
complies for reaction against H2SO4

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

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This Item
27102C1909C0706
Citric acid monohydrate puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., buffer substance, 99.5-102%

Sigma-Aldrich

33114

Citric acid monohydrate

-
Citric acid monohydrate puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

Sigma-Aldrich

27102

Citric acid monohydrate

-
Citric acid monohydrate ACS reagent, ≥99.0%

Sigma-Aldrich

C1909

Citric acid monohydrate

-
Citric acid monohydrate BioXtra, ≥99.5%

Sigma-Aldrich

C0706

Citric acid monohydrate

Premium Grade
agency

USP/NF, reag. ISO, reag. Ph. Eur.

agency

-

agency

-

agency

-

assay

99.5-100.5% (calc. on anhydrous substance), 99.5-102%

assay

99.5-100.5% (based on anhydrous substance)

assay

≥99.0%

assay

≥99.5%

form

solid

form

grit

form

powder

form

powder

impurities

≤0.005% insolubles in water, ≤2 ppm heavy metals (as Pb), 7.5-9.0% water (Karl Fischer)

impurities

residual solvents, complies, ≤0.0005% heavy metals (as Pb), 7.5-8.8% water (Karl Fischer)

impurities

Substances carbonizable by hot sulfuric acid, passes test, ≤0.005% Insoluble matter

impurities

≤0.002% Phosphorus (P), ≤0.005% Insoluble matter

anion traces

chloride (Cl-): ≤5 mg/kg, oxalate (C2O42-): ≤50 ppm, phosphate (PO43-): ≤10 mg/kg, sulfate (SO42-): ≤20 ppm

anion traces

chloride (Cl-): ≤50 mg/kg, oxalate (as oxalic acid): ≤100 mg/kg, sulfate (SO42-): ≤100 mg/kg

anion traces

chloride (Cl-): ≤0.001%, oxalate (C2O42-): passes test (limit about 0.05%), phosphate (PO43-): ≤0.001%, sulfate (SO42-): ≤0.002%

anion traces

chloride (Cl-): ≤0.001%, sulfate (SO42-): ≤0.002%

General description

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061 ± 123)Jmol-1.

Application

Citric acid monohydrate may be used in the preparation of tris-citrate buffer and Otto I isolation buffer used in bioprotocols. It may also be used to improve the release of diltiazem hydrochloride from melt extruded matrix tablets.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

345.0 °F - closed cup

Flash Point(C)

173.9 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Citric acid monohydrate as a release-modifying agent in melt extruded matrix tablets.
Schilling SU, et al.
International Journal of Pharmaceutics, 361(1), 158-168 (2008)
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Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics.
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International journal of pharmaceutics, 361(1-2), 158-168 (2008-06-28)
Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem
S Massberg et al.
The Journal of experimental medicine, 189(8), 1255-1264 (1999-04-20)
Atherosclerotic vascular lesions are considered to be a major cause of ischemic diseases, including myocardial infarction and stroke. Platelet adhesion and aggregation during ischemia-reperfusion are thought to be the initial steps leading to remodeling and reocclusion of the postischemic vasculature.

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