918660

γ-Valerolactone

BioRenewable, ≥99%, ReagentPlus^®

• Synonym(s): γ-Methyl-γ-butyrolactone, 4,5-Dihydro-5-methyl-2(3H)-furanone, 4-Hydroxypentanoic acid lactone
• Empirical Formula (Hill Notation): C₅H₈O₂
• CAS Number: 108-29-2
• Molecular Weight: 100.12
• Beilstein: 80420
• MDL number: MFCD00005400

Properties

• vapor density: 3.45 (vs air)
• Quality Level: 100
• product line: ReagentPlus^®
• Assay: ≥99%
• form: liquid
• greener alternative product characteristics: Safer Solvents and Auxiliaries; Use of Renewable Feedstocks; Design for Degradation; Learn more about the Principles of Green Chemistry.
• refractive index: n20/D 1.432 (lit.)
• bp: 207-208 °C (lit.); 82-85 °C/10 mmHg (lit.)
• mp: −31 °C (lit.)
• density: 1.05 g/mL at 25 °C (lit.)
• greener alternative category: Aligned
• SMILES string: CC1CCC(=O)O1
• InChI: 1S/C5H8O2/c1-4-2-3-5(6)7-4/h4H,2-3H2,1H3
• InChI key: GAEKPEKOJKCEMS-UHFFFAOYSA-N

Description

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. γ-Valerolactone (GVL) is a dipolar aprotic, bio-based, fully degradable, non-toxic green solvent and has been aligned with "Safer Solvent and Auxiliaries", "Use of Renewable Feedstocks" and "Design for Degradation". Click here for more information. γ-Valerolactone is a sustainable alternative to traditional solvents such as NMP and DMF.



We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. γ-Valerolactone (GVL) is a bio-based, fully degradable, non-toxic green solvent and has been aligned with "Safer Solvent and Auxiliaries", "Use of Renewable Feedstocks" and "Design for Degradation". Click here for more information.

Application

Cross-coupling reactions

• HATU Amide Coupling
• Suzuki-Miyaura coupling reaction
• Sonogashira coupling reaction

ATRP polymerization

• Replacement of DCM in peptide synthesis

Features and Benefits

• Made from Renewable Resource - rice
• Biodegradable
• Non-toxic
• Low vapor pressure
  

Other Notes

To see other BioRenewable or Greener Solvents

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 204.8 °F - closed cup
• Flash Point(C): 96 °C - closed cup