Merck
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D6518

Sigma-Aldrich

Diethylenetriaminepentaacetic acid

≥99% (titration)

Synonym(s):
(Carboxymethylimino)bis(ethylenenitrilo)tetraacetic acid, N,N-Bis(2-[bis(carboxymethyl)amino]ethyl)glycine, DETAPAC, DTPA, Penta(carboxymethyl)diethylenetriamine, Pentetic acid
Linear Formula:
[(HOOCCH2)2NCH2CH2]2NCH2COOH
CAS Number:
Molecular Weight:
393.35
Beilstein:
1810219
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

Assay

≥99% (titration)

form

powder

mp

219-220 °C (lit.)

solubility

1 M HCl: 50 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O

InChI

1S/C14H23N3O10/c18-10(19)5-15(1-3-16(6-11(20)21)7-12(22)23)2-4-17(8-13(24)25)9-14(26)27/h1-9H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,26,27)

InChI key

QPCDCPDFJACHGM-UHFFFAOYSA-N

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1 of 4

This Item
1.083901505506PHR2645
Pentetic acid United States Pharmacopeia (USP) Reference Standard

USP

1505506

Pentetic acid

Pentetic Acid Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2645

Pentetic Acid

assay

≥99% (titration)

assay

-

assay

-

assay

-

form

powder

form

solid

form

-

form

solid

mp

219-220 °C (lit.)

mp

>206 °C (Decomposition)

mp

219-220 °C (lit.)

mp

219-220 °C (lit.)

solubility

1 M HCl: 50 mg/mL, clear, colorless

solubility

4.8 g/L

solubility

-

solubility

-

storage temp.

room temp

storage temp.

15-25°C

storage temp.

-

storage temp.

2-30°C

General description

Diethylenetriaminepentaacetic acid is a diethylenetriaminepentaacetic anhydride, which is a bifunctional chelating agent. It is used for the treatment of poisoning.

Application

Diethylenetriaminepentaacetic acid has been used:
  • for cofilin activity assay
  • to determine the specificity of superoxide in the transverse aortic constriction (TAC) hearts
  • for Europium bead-based detection assays
  • to detect reduced (S- active) or irreversibly oxidized (SO3H inactive) tyrosine-protein phosphatase non-receptor type 6 (SHP-1) in thymocytes

Preparation Note

Purified

Pictograms

Exclamation markHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation

Target Organs

Respiratory Tract

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

392.0 °F - closed cup

Flash Point(C)

200 °C - closed cup


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Detection of Intracellular Reduced (Catalytically Active) SHP-1 and Analyses of Catalytically Inactive SHP-1 after Oxidation by Pervanadate or H2O2
Choi S and Love PE
Bio-protocol, 8(1) (2018)
Paraoxonase 2 prevents the development of heart failure
Li W, et al.
Free Radical Biology & Medicine, 121, 117-126 (2018)
Bioconjugate Techniques (2013)
Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization
Piroli GG, et al.
Molecular and Cellular Proteomics, mcp-RA118 (2018)
Highly stable lyophilized homogeneous bead-based immunoassays for on-site detection of bio warfare agents from complex matrices
Mechaly A, et al.
Analytical Chemistry, 88(12), 6283-6291 (2016)

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