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PHR1005

Supelco

Acetaminophen

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
APAP, N-Acetyl-4-aminophenol, Paracetamol, 4-Acetamidophenol, 4′-Hydroxyacetanilide, N-(4-Hydroxyphenyl)acetamide
Linear Formula:
CH3CONHC6H4OH
CAS Number:
Molecular Weight:
151.16
Beilstein:
2208089
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

application(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

168-172 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to BP 371
traceable to PhEur P030000
traceable to USP 1003009

SMILES string

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

InChI key

RZVAJINKPMORJF-UHFFFAOYSA-N

Gene Information

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General description

Acetaminophen is a drug, which possesses pharmacological properties like antipyretic and analgesic property.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Acetaminophen may be used as a standard in the determination of acetaminophen in human serum or plasma samples using spectrophotometric technique. It may also be used as a standard in the estimation of acetaminophen in pharmaceutical formulations using high performance liquid chromatography (HPLC).
Analgesic.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7782 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

364.3 °F - Pensky-Martens closed cup

Flash Point(C)

184.6 °C - Pensky-Martens closed cup

Certificate of Analysis

Certificate of Origin

Spectrophotometric Screening Method for Acetaminophen in Serum and Plasma
Liu.ZT and Oka.HK
Clinical Chemistry, 26, 69-71 (1980)
Reversed-phase HPLC method for the estimation of acetaminophen, ibuprofen and chlorzoxazone in formulations
Ravisankar.S, et al.
Talanta, 46, 1577-1581 (1998)
Simultaneous high-performance liquid chromatographic stability-indicating analysis of acetaminophen and codeine phosphate in tablets and capsules
Sisco.RW, et al.
Journal of Chromatography A, 348, 253-263 (1985)
Elizabeth A Davis et al.
Current biology : CB, 30(22), 4510-4518 (2020-09-19)
Vagal afferent neuron (VAN) signaling sends information from the gut to the brain and is fundamental in the control of feeding behavior and metabolism [1]. Recent findings reveal that VAN signaling also plays a critical role in cognitive processes, including...
S M de Morais et al.
Gastroenterology, 102(2), 577-586 (1992-02-01)
Gilbert's syndrome occurs in 5%-7% of the human population and is caused by an inherited deficiency in the glucuronidation of endogenous bilirubin, resulting in its accumulation and jaundice. The authors of the present study have previously shown that rats with...

Articles

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Separation of Acetaminophen, meets USP testing specifications, 98.0-102.0%, powder; Caffeine, meets USP testing specifications, anhydrous; Benzoic acid, meets USP testing specifications; Aspirin, meets USP testing specifications

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