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PHR1031

Supelco

Alpha Tocopherol

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
(±)-α-Tocopherol, DL-all-rac-α-Tocopherol, Vitamin E
Empirical Formula (Hill Notation):
C29H50O2
CAS Number:
Molecular Weight:
430.71
Beilstein:
94012
EC Number:
MDL number:
eCl@ss:
34058016
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to BP 882
traceable to Ph. Eur. T1550000
traceable to USP 1667600

API family

tocopherol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

density

0.950 g/mL at 20 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1

InChI

1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3

InChI key

GVJHHUAWPYXKBD-UHFFFAOYSA-N

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This Item
906692580241667600
Alpha Tocopherol Pharmaceutical Secondary Standard; Certified Reference Material

PHR1031

Alpha Tocopherol

(±)-α-Tocopherol tested according to Ph. Eur.

90669

(±)-α-Tocopherol

α-Tocopherol ≥95.5%

258024

α-Tocopherol

Alpha Tocopherol United States Pharmacopeia (USP) Reference Standard

1667600

Alpha Tocopherol

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable

technique(s)

-

format

neat

format

-

format

-

format

neat

Quality Level

300

Quality Level

200

Quality Level

-

Quality Level

-

grade

certified reference material, pharmaceutical secondary standard

grade

-

grade

-

grade

pharmaceutical primary standard

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

α-Tocopherol is a powerful biological antioxidant and the most active form of vitamin E in humans.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

α-Tocopherol may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using flow injection chemiluminescence technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3718 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup


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Simultaneous determination of retinol and alpha-tocopherol in serum or plasma by liquid chromatography
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Protocols

HPLC Analysis of Fat Soluble Vitamins by Normal Phase Chromatography on Ascentis® S

Separation of δ-Tocopherol, analytical standard; Retinyl acetate; (+)-γ-Tocopherol; α-Tocopherol, ≥95.5%; Retinol; Vitamin A (acetate), meets USP testing specifications.

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