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Propylene glycol

Pharmaceutical Secondary Standard; Certified Reference Material

Propylene glycol, 1,2-Propanediol
Linear Formula:
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:
E Number:

Quality Level


certified reference material
pharmaceutical secondary standard

vapor density

2.62 (vs air)

vapor pressure

0.08 mmHg ( 20 °C)




current certificate can be downloaded

autoignition temp.

779 °F

expl. lim.

12.5 %


HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.432 (lit.)


187 °C (lit.)


−60 °C (lit.)


1.036 g/mL at 25 °C (lit.)

Featured Industry

Cleaning Products
Flavors and Fragrances
Food and Beverages
Personal Care
Pharmaceutical (small molecule)



pharmacopeia traceability

traceable to USP 1576708

SMILES string




InChI key


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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Propylene glycol is commonly utilized as a penetration enhancer in topical dermatological formulations, either alone or in combined form with other penetration enhancing agents, like fatty acids.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Propylene glycol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAB9658 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

10 - Combustible liquids

WGK Germany


Flash Point F

217.4 °F - closed cup

Flash Point C

103 °C - closed cup

Certificate of Analysis

Certificate of Origin

Analysis of aldehydes in excipients used in liquid/semi-solid formulations by gas chromatography-negative chemical ionization mass spectrometry
Li Z, et al.
Journal of Chromatography A, 1160(1-2), 299-305 (2007)
Effect of finite doses of propylene glycol on enhancement of in vitro percutaneous permeation of loperamide hydrochloride
Trottet L, et al.
International Journal of Pharmaceutics, 274(1-2), 213-219 (2004)
Gai Ling Li et al.
Journal of controlled release : official journal of the Controlled Release Society, 84(1-2), 49-57 (2002-10-26)
To achieve a therapeutical effect of the anti-Parkinson's drug R-apomorphine via iontophoresis delivery, enhancement strategies in vitro were explored using three structurally related enhancers, lauric acid (LA), dodecyltrimethylammonium bromide (DTAB) and Laureth-3 oxyethylene ether (C(12)EO(3)). Human stratum corneum and shed...
H K Vaddi et al.
Journal of pharmaceutical sciences, 91(7), 1639-1651 (2002-07-13)
The respective alcoholic terpenes carvacrol, linalool, and alpha-terpineol were used at 5% w/v in propylene glycol (PG) to increase the in vitro permeation of haloperidol (HP) through human skin. The possible enhancement mechanism was then elucidated with HP-stratum corneum (SC)...
G A Reichard et al.
Diabetes, 35(6), 668-674 (1986-06-01)
Plasma acetone turnover rates were measured with the primed continuous infusion of 2-[14C]acetone in patients with moderate to severe diabetic ketoacidosis. Plasma acetone turnover rates ranged from 1.52 to 15.9 mumol X kg-1 X min-1 (108-1038 mumol X 1.73 m-2...


GC Analysis of Glycols on Nukol™

99%; Glycerol, ≥99.5%; Tetraethylene glycol, 99%

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