338826

Acetic acid

glacial, ≥99.99% trace metals basis

• Synonym(s): Glacial acetic acid
• Linear Formula: CH₃CO₂H
• CAS Number: 64-19-7
• Molecular Weight: 60.05
• Beilstein: 506007
• EC Number: 200-580-7
• MDL number: MFCD00036152
• PubChem Substance ID: 329754692
• NACRES: NA.21

Properties

• vapor density: 2.07 (vs air)
• Quality Level: 100
• Assay: ≥99.99% trace metals basis
• form: liquid
• autoignition temp.: 800 °F
• expl. lim.: 16 %, 92 °F; 4 %, 59 °F
• technique(s): HPLC: suitable
• refractive index: n20/D 1.371 (lit.)
• pH: 2.5 (20 °C, 50 g/L)
• bp: 117-118 °C (lit.)
• mp: 16.2 °C (lit.)
• density: 1.049 g/mL at 25 °C (lit.)
• SMILES string: CC(O)=O
• InChI: 1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)
• InChI key: QTBSBXVTEAMEQO-UHFFFAOYSA-N

Description

Application

Acetic acid can be used as a catalyst:

• For the solvent-free one-pot condensation of indoles with aryl or heteroaryl aldehydes to synthesize di(indolyl)methanes.
• In the Pictet-Spengler reaction of substituted tryptamines with cyclic ketones to synthesize tetrahydrospiro-Ͱ-carbolines.
• To synthesize trisubstituted thiazoles via domino multicomponent reaction.

It can also be used as a:

• solvent to synthesize aryl amine-functionalized 1,3,5-triazine derivatives via aryl amination of cyanuric chloride with aromatic amines.

Safety Information

• Pictograms: GHS02,GHS05
• Signal Word: Danger
• Hazard Statements: H226 - H314
• Precautionary Statements: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 102.2 °F
• Flash Point(C): 39 °C