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M0695

Sigma-Aldrich

Anti-MOG (N-terminal) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-Myelin-oligodendrocyte Glycoprotein
MDL number:
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

western blot: 1-2 μg/mL using recombinant human MOG protein

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MOG(4340)

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This Item
SAB2500639SAB1410792HPA021873
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

species reactivity

human

species reactivity

bovine, mouse, rat, human

species reactivity

human

species reactivity

human

General description

Myelin/oligodendrocyte glycoprotein (MOG) is an integral membrane glycoprotein belonging to the large immunoglobulin superfamily. It is a 26-28kDa glycoprotein localized on chromosome 6p21.3. It consists of an extracellular immunoglobulin-like domain and two hydrophobic regions. It is expressed on the surface of myelinating oligodendrocytes and external lamellae of myelin sheaths in the central nervous system.

Immunogen

synthetic peptide corresponding to amino acids 84-100 located near the N-terminal region of human MOGα1 isoform, conjugated to KLH. This sequence is identical in human MOGα1-3 and MOGβ1-4 isoforms, deleted in MOGα4 isoform, and identical in rat, mouse, and bovine MOG.

Application

Anti-MOG (N-terminal) antibody produced in rabbit is suitable for western blot at a concentration of 1-2μg/mL using recombinant human MOG protein.

Biochem/physiol Actions

Myelin/oligodendrocyte glycoprotein (MOG) is a major component of the central nervous system. It is involved in several cellular processes including cellular adhesion, in the regulation of oligodendrocyte microtubule stability and facilitates the interactions between myelin and the immune system. It has been reported that MOG may be involved in the completion and/or maintenance of the myelin sheath, and in cell-cell communication. It has also been observed that mutation or polymorphisms in MOG gene could cause multiple sclerosis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Ying Peng et al.
Experimental and therapeutic medicine, 16(2), 950-958 (2018-08-17)
The present study aimed to detect myelin oligodendrocyte glycoprotein (MOG) and aquaporin-4 (AQP4) antibodies in serum specimens of patients with recurrent optic neuritis (RON) through establishing 293 cells with stable expression of MOG and the complete genomic sequence as the
Nanping Ai et al.
Neuropsychiatric disease and treatment, 15, 303-310 (2019-02-06)
To study the differences in immunopathogenesis based on chemokine profile in neuromyelitis optica patients positive for AQP4 antibodies or MOG antibodies. We measured 52 cytokines/chemokines using ELISA in 59 serum samples, which were divided into three groups according to CBA
Natalia Lubina-Dąbrowska et al.
Archivum immunologiae et therapiae experimentalis, 65(4), 325-338 (2017-03-17)
The aim of this study was to investigate the effects of interferon (IFN)-β1a and IFN-β1b treatment on inflammatory factors and myelin protein levels in the brain cortex of the Lewis rat experimental autoimmune encephalomyelitis (EAE), animal model of multiple sclerosis.
T G Johns et al.
Journal of neurochemistry, 72(1), 1-9 (1999-01-14)
Myelin oligodendrocyte glycoprotein (MOG) is a quantitatively minor component of CNS myelin whose function remains relatively unknown. As MOG is an autoantigen capable of producing a demyelinating multiple sclerosis-like disease in mice and rats, much of the research directed toward
B della Gaspera et al.
European journal of biochemistry, 258(2), 478-484 (1999-01-05)
Myelin/oligodendrocyte glycoprotein (MOG), a specific component of the mammalian central nervous system, is located on the surface of the oligodendrocyte plasma membrane and the outermost lamellae of mature myelin; it is expressed during the latter steps of myelinogenesis. It has

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