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SRP0113

Sigma-Aldrich

HDAC-11 human

recombinant, expressed in baculovirus infected insect cells, ≥10% (SDS-PAGE)

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Synonym(s):
HD11, Histone deacetylase 11

biological source

human

recombinant

expressed in baculovirus infected insect cells

Assay

≥10% (SDS-PAGE)

form

aqueous solution

mol wt

66 kDa

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

>0.02 mg/mL

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... HDAC11(79885)

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SRP0110SRP0100SRP0109
HDAC-11 human recombinant, expressed in baculovirus infected insect cells, ≥10% (SDS-PAGE)

Sigma-Aldrich

SRP0113

HDAC-11 human

HDAC-8 human recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE)

Sigma-Aldrich

SRP0110

HDAC-8 human

HDAC-1 human recombinant, expressed in baculovirus infected insect cells, ≥50% (SDS-PAGE)

Sigma-Aldrich

SRP0100

HDAC-1 human

HDAC-7 human recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE)

Sigma-Aldrich

SRP0109

HDAC-7 human

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

assay

≥10% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

assay

≥50% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

form

aqueous solution

form

aqueous solution

form

aqueous solution

form

aqueous solution

mol wt

66 kDa

mol wt

42.4 kDa

mol wt

56 kDa

mol wt

78 kDa

storage condition

avoid repeated freeze/thaw cycles

storage condition

avoid repeated freeze/thaw cycles

storage condition

avoid repeated freeze/thaw cycles

storage condition

avoid repeated freeze/thaw cycles

General description

HDAC-11 (histone deacetylase 11) is a zinc-dependent HDAC. It belongs to the HDAC family of proteins and HDAC class IV. It is highly conserved among various species. The mRNA is present in the brain, skeletal muscle, kidney and testis. The gene is mapped to human chromosome 3p25.
Human HDAC11, full length, GenBank Accession No. BC009676, with N-terminal GST tag, MW = 66kDa, expressed in baculovirus expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Biochem/physiol Actions

HDAC-11 (histone deacetylase 11) is responsible for deacetylation of nuclear histone and nonhistone proteins, including transcription factors. HDAC-11 catalyzes the deacetylation of histone H4. It binds to CDT1 (DNA replication factor) and is present with S phase-associated replication origins. HDAC-11 is upregulated in various carcinomas. Absence of it results in cell death and suppresses metabolic activity in colon, prostate, breast and ovarian cancer cell lines.

Unit Definition

One unit is defined as the amount of enzyme required to deacetylate 1 pmol of substrate/min at 37°C.

Physical form

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 50% glycerol.

Preparation Note

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma.
Buglio D, et al.
Blood, 117, 2910-2910 (2011)
Chromosomal organization and localization of the novel class IV human histone deacetylase 11 gene.
Voelter-Mahlknecht S, et al.
International Journal of Molecular Medicine, 16, 589-589 (2005)
Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin.
Wong PG, et al.
Cell Cycle, 9, 4351-4351 (2010)
HDAC11 is a novel drug target in carcinomas.
Deubzer HE, et al.
International Journal of Cancer. Journal International Du Cancer, 132, 2200-2200 (2013)

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